Multicompartment combinatory pre-clinical model for melanoma drug screening
One of the biggest limitations in developing new treatments for cutaneous melanoma relies on overcoming the inefficient screening, often to animal models, which greatly differ from humans. Also, the 3Rs principle limits the numb...
One of the biggest limitations in developing new treatments for cutaneous melanoma relies on overcoming the inefficient screening, often to animal models, which greatly differ from humans. Also, the 3Rs principle limits the number of therapeutics that actually reach the in vivo evaluation of product/drug development or discovery. Thus, there is a high demand for novel pre-clinical platforms, as alternative models to the use of animals, that can screening new treatments. I propose the establishment of a multicompartmental melanoma graft model based on an ex vivo skin tissue grafted with a multicellular spheroid composed by melanoma cells, keratinocytes and monocytes. The ex vivo melanoma graft model, called SkinModelOma, will be a major breakthrough in the study of melanoma tumor growth and on the effectiveness of new therapies in different types of skin and considering gender and age. To the best of my knowledge, this will be the first ex vivo melanoma graft model, and the first model for skin cancer considering age, gender and skin type as important parameters in novel therapies screening for skin cancer. This proposal includes 3 scientific work packages related to 3 objectives and includes transversal work packages related to my training and improviment as a researcher. The objectives are based in the development and standardization of multicellular spheroid, their graft in the human skin and the validation of this model as a screening platform. I believed that the SkinModelOma proposed here will contribute to significant scientific advances in cutaneous melanoma patients’ management and also to great international recognition that will enable other researchers to benefit from a novel pre-clinical tool.ver más
Seleccionando "Aceptar todas las cookies" acepta el uso de cookies para ayudarnos a brindarle una mejor experiencia de usuario y para analizar el uso del sitio web. Al hacer clic en "Ajustar tus preferencias" puede elegir qué cookies permitir. Solo las cookies esenciales son necesarias para el correcto funcionamiento de nuestro sitio web y no se pueden rechazar.
Cookie settings
Nuestro sitio web almacena cuatro tipos de cookies. En cualquier momento puede elegir qué cookies acepta y cuáles rechaza. Puede obtener más información sobre qué son las cookies y qué tipos de cookies almacenamos en nuestra Política de cookies.
Son necesarias por razones técnicas. Sin ellas, este sitio web podría no funcionar correctamente.
Son necesarias para una funcionalidad específica en el sitio web. Sin ellos, algunas características pueden estar deshabilitadas.
Nos permite analizar el uso del sitio web y mejorar la experiencia del visitante.
Nos permite personalizar su experiencia y enviarle contenido y ofertas relevantes, en este sitio web y en otros sitios web.