Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SkinModelOma

Financiado

Multicompartment combinatory pre-clinical model for melanoma drug screening

One of the biggest limitations in developing new treatments for cutaneous melanoma relies on overcoming the inefficient screening, often to animal models, which greatly differ from humans. Also, the 3Rs principle limits the numb... ver más

31/05/2025

I3S INSTITUTO DE...

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

I3S INSTITUTO DE INVESTIGACAO E INOVACAO EM... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-10

HORIZON-WIDERA-2022-TALENTS-04-01: Fostering balanced brain circulatio... ExpectedOutcome:This action will build on the MSCA Postdoctoral Fellowships 2022 action (HORIZON-MSC...

I+D

Cerrada hace 2 años

0% 100%

1 Participantes

I3S INSTITUTO DE INVESTIGAC...

172.62K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

PDC2022-133826-I00 PLATAFORMA DE CO-CULTIVO IN VITRO CON GLIO-ORGANOIDES PARA B... 115K€ Cerrado

PCI2024-153529 Cáncer 235K€ Cerrado

PID2021-122409OB-C21 MODELADO PREDICTIVO Y SIMULACION DE ORGANOIDES TUMORALES DER... 182K€ Cerrado

Decode Relapse Decoding and Targeting Treatment-Resistant Metastatic Neurob... 2M€ Cerrado

RTC2019-007028-1 Desarrollo preclínico y regulatorio de terapias CAR-T modula... 2K€ Cerrado

PID2021-126523OB-I00 DESARROLLO DE UN MODELO TRIDIMENSIONAL DE MELANOMA DINAMICO,... 115K€ Cerrado

Duración del proyecto: 24 meses Fecha Inicio: 2023-05-10
Fecha Fin: 2025-05-31

Líder del proyecto

I3S INSTITUTO DE INVESTIGACAO E INOVACAO EM... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 173K€

Descripción del proyecto One of the biggest limitations in developing new treatments for cutaneous melanoma relies on overcoming the inefficient screening, often to animal models, which greatly differ from humans. Also, the 3Rs principle limits the number of therapeutics that actually reach the in vivo evaluation of product/drug development or discovery. Thus, there is a high demand for novel pre-clinical platforms, as alternative models to the use of animals, that can screening new treatments. I propose the establishment of a multicompartmental melanoma graft model based on an ex vivo skin tissue grafted with a multicellular spheroid composed by melanoma cells, keratinocytes and monocytes. The ex vivo melanoma graft model, called SkinModelOma, will be a major breakthrough in the study of melanoma tumor growth and on the effectiveness of new therapies in different types of skin and considering gender and age. To the best of my knowledge, this will be the first ex vivo melanoma graft model, and the first model for skin cancer considering age, gender and skin type as important parameters in novel therapies screening for skin cancer. This proposal includes 3 scientific work packages related to 3 objectives and includes transversal work packages related to my training and improviment as a researcher. The objectives are based in the development and standardization of multicellular spheroid, their graft in the human skin and the validation of this model as a screening platform. I believed that the SkinModelOma proposed here will contribute to significant scientific advances in cutaneous melanoma patients’ management and also to great international recognition that will enable other researchers to benefit from a novel pre-clinical tool.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores