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MUC-BITE

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Mucinase-based innovative therapy to enhance cancer treatment

Colorectal carcinoma (CRC) is one of the leading causes of cancer death in women and men. CRC can be broadly subdivided into adenocarcinoma-type and mucinous-type CRC, characterised by an overproduction of mucin proteins which is... see more

30/06/2024

150K€

Project Budget: 150K€

Project leader

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-06-30

ERC-2022-POC2: ERC PROOF OF CONCEPT GRANTS2 Objective:Objectives:

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

150.00K€ | Leader

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Project duration: 19 months Date Start: 2022-11-18
End date: 2024-06-30

Project leader

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 150K€

participation deadline Sin fecha límite de participación.

Project description Colorectal carcinoma (CRC) is one of the leading causes of cancer death in women and men. CRC can be broadly subdivided into adenocarcinoma-type and mucinous-type CRC, characterised by an overproduction of mucin proteins which is the primary component of mucus. These mucins form a 'physical barrier' that impedes the accessibility of current CRC therapies to their target receptors, limiting what would otherwise be promising cancer drugs. Dr. Karin Strijbis' group has discovered a compelling mucinase enzyme that can effectively degrade the mucin barrier. Preliminary research performed by Dr. Strijbis' group revealed this mucinase's therapeutic potential to enhance the effectivity of approved anti-CRC drugs (i.e., anti-EGFR antibodies and small molecule inhibitors) by demonstrating the removal of obstructive mucin proteins and a decrease in CRC cell proliferation. In MUC-BITE, we present Nano-MUCase, a novel biological based on the conjugation of this mucinase with a nanobody to selectively target CRC tumours for optimal delivery and removal of the mucin barrier. During this PoC project, we will determine the technical and commercial feasibility Nano-MUCase through the following activities: 1. Validate the capabilities of the Nano-MUCase to target CRC tumours and reduce mucin interference of anti-CRC drugs in organoid samples and in vivo. 2. Define an IP strategy by performing a thorough IP landscape and patentability analysis. 3. Conduct market research to discover potential customers/industrial partners, analyse competitors and identify a feasible roadmap to commercialisation. 4. Formulate a detailed business case to guide the commercialisation of the Nano-MUCase to penetrate the market and deliver a new therapeutic strategy to benefit CRC patients.

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