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ZIKVMosTransmit

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Molecular mechanisms underlying Zika virus transmission by Aedes aegypti mosquit...

Molecular mechanisms underlying Zika virus transmission by Aedes aegypti mosquitoes The public health response to emerging mosquito-borne viral diseases is often inefficient, because the causative agents are recognized and the prevention measures are deployed, only after the disease has spread. To predict which v... ver más

15/01/2025

196K€

Presupuesto del proyecto: 196K€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-07-04

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

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1 Participantes

195.91K€ | Lider

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Duración del proyecto: 30 meses Fecha Inicio: 2022-07-04
Fecha Fin: 2025-01-15

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 196K€

Descripción del proyecto The public health response to emerging mosquito-borne viral diseases is often inefficient, because the causative agents are recognized and the prevention measures are deployed, only after the disease has spread. To predict which viruses and mosquitoes have the highest potential to cause future outbreaks, understanding the mechanisms determining the virus susceptibility of mosquitoes and the mosquito transmissibility of viruses is needed. In this study, I propose a two-pronged approach to identify both the viral and mosquito factors involved in molecular compatibility between the human pathogenic Zika virus and its main vector Aedes aegypti by combining my skills in molecular virology with the host lab’s expertise in mosquito experimental infections in vivo. First, I will examine the mosquito-virus protein interactome by a proteomics strategy based on cross-linking, immunoaffinity purification and mass spectrometry. Mosquito factors regulating virus susceptibility will be identified by subtractive comparison of virus-binding mosquito proteins between two mosquito strains displaying different levels of Zika virus susceptibility. The correlation between virus susceptibility and the identified proteins will be validated by gene-knockdown assays and expression surveys using a collection of mosquito strains. Second, I will use an innovative reverse genetics system to create chimeric Zika viruses from two parental virus strains with different levels of mosquito transmissibility. The viral genes required for efficient transmission by mosquitoes will be identified by comparing transmissibility between chimeric constructs. Together, this project will provide important new insights into vector-virus specificity and significantly improve our understanding of mosquito-borne virus emergence.

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