Innovating Works

BRAINTIME

Financiado
Molecular atlas of the brain across the human lifespan
BRAINTIME brings together six laboratories that are international leaders in the field of single-cell genomics with the aim to apply their knowledge and expertise to understand the human brain. In BRAINTIME, we will: (1) Perform a... BRAINTIME brings together six laboratories that are international leaders in the field of single-cell genomics with the aim to apply their knowledge and expertise to understand the human brain. In BRAINTIME, we will: (1) Perform a comprehensive multi-omic analysis of the developing human midbrain and hindbrain to generate an atlas of key monoaminergic cell populations in healthy adulthood, ageing and neurodegenerative disease; (2) Embed our new cell type maps into 3D contexts and temporal developmental models by integrating new approaches for computational modelling, cell fate tracking, spatial analysis and capturing cell-cell interactions; (3) Establish single-cell genomics-empowered ex-vivo protocols and standardized ex-vivo/in-vivo projection algorithms to allow flexible model testing and perturbation analysis on midbrain and hindbrain tissues; (4) Establish an effective and sustainable technological and analytical pipeline for the analysis of brain tissue at the single-cell level that can be used by the community to probe other brain regions or states and be extended to other human tissues. Achieving these objectives will significantly advance the Human Cell Atlas initiative by contributing major new datasets on human brain development and ageing, and ensure a key role for European labs in the global effort. Through the US partner (Ed Lein / Allen Institute), a crucial connection to the NIH BRAIN initiative will be ensured, including access to significant computational and atlasing resources. Through the SME partner (CartaNA), we gain access to cutting edge in-situ sequencing methods and support the fledgling European biotech industry in the single-cell field. ver más
30/06/2022
KI
4M€
Duración del proyecto: 30 meses Fecha Inicio: 2019-12-06
Fecha Fin: 2022-06-30

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2022-06-30
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
SC1-BHC-31-2019: Pilot actions to build the foundations of a human cell atlas
Cerrada hace 5 años
Presupuesto El presupuesto total del proyecto asciende a 4M€
Líder del proyecto
KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5