Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ZEBRAPROTECT

Financiado

Cerrado

Molecular and ecological characterisation of bacterial community mediated protec...

Molecular and ecological characterisation of bacterial community mediated protection against infection in the zebrafish "Animal-associated commensal microbiota play a crucial role in protecting their hosts against invading pathogens through a process called colonisation resistance. A number of hypotheses have been proposed to explain this protectiv... ver más

28/02/2015

194K€

Presupuesto del proyecto: 194K€

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2015-02-28 No tenemos la información de la convocatoria

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

0.00€ | Lider

Proyectos interesantes

MICROINVADER

Medical Technol...

Data Science

196K€ Cerrado

Experimental Microbiome

Medical Technol...

Data Science

173K€ Cerrado

METEOR study

Medical Technol...

Data Science

193K€ Cerrado

PATHOCOM

Medical Technol...

Data Science

10M€ Cerrado

SAF2012-31187

Medical Technol...

Data Science

380K€ Cerrado

MUSMICRO

Medical Technol...

Data Science

2M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

INSTITUT PASTEUR No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 194K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Animal-associated commensal microbiota play a crucial role in protecting their hosts against invading pathogens through a process called colonisation resistance. A number of hypotheses have been proposed to explain this protective effect. These include direct competition between commensal and pathogens (barrier effect), alteration of the host immune defence (immuno-stimulation), or protection by certain species but not the whole community (membership effect). Investigations of bacterial community interactions were carried out extensively based on genomic approaches, but functional studies are still rare. Indeed, investigating bacterial interactions in vivo is often hindered by the complexity of host-associated bacterial communities and a lack of appropriate direct and reproducible experimental approaches for the analysis of community-based colonisation resistance. We propose an innovative approach using the zebrafish (Danio rerio) as a relevant vertebrate model to systematically dissect the mechanisms behind community-protection against exogenous pathogens. Our preliminary data showed that axenic and mono-colonised, but not conventional zebrafish larvae harbouring natural microbiota, rapidly die upon infection by the fish pathogen Flavobacterium columnare. We will use conventional zebrafish survival as a read-out for community-protection and will investigate its molecular and ecological bases. Culturable bacteria isolated from natural zebrafish microbiota will be transplanted into axenic fish to determine key species involved in protection and construct a minimum protective community. We will then characterise the community interactions with ecological tools and identify the molecular determinants for the protection against F. columnare. This approach will generate fundamental knowledge about microbial ecological interactions in host-associated systems and could contribute to a better understanding of strategies for pathogen control."

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores