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SHIKIFACTORY100

Financiado

Cerrado

Modular cell factories for the production of 100 compounds from the shikimate pa...

Modular cell factories for the production of 100 compounds from the shikimate pathway Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a weal... ver más

30/06/2023

SILICOLIFE LDA

8M€

Presupuesto del proyecto: 8M€

Líder del proyecto

SILICOLIFE LDA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 14 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-06-30

BIOTEC-03-2018: Synthetic biology to expand diversi... Specific Challenge:For years, industries have relied upon living organisms as a source of compounds...

I+D

Cerrada hace 7 años

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Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

14 Participantes

SILICOLIFE LDA

1.23M€ | Lider

ELECTROTECNICA ARTECHE SMART...

748.20K€ | Participante

UPV

2.19K€ | Participante

GALCHIMIA

495.24K€ | Participante

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Duración del proyecto: 54 meses Fecha Inicio: 2018-12-12
Fecha Fin: 2023-06-30

Líder del proyecto

SILICOLIFE LDA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 8M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a wealth of products, however typically at very low concentrations, which makes their extraction process expensive. Conversely, microbial production is a well-established process for compounds naturally produced by the hosts or for which there are fully characterised biosynthetic pathways. However, relying on nature’s diversity as a provider for industrial applications typically requires major screenings for pathways, genes and optimisation of cell factories for the efficient production of the target compounds. SHIKIFACTORY100 project aims towards the production of a universe of more than 100 high-added value compounds from the shikimate pathway, a hub in cell metabolism, through the development of an optimised shikimate chassis) and the proposal and implementation of novel biosynthetic routes exploring enzyme promiscuity to propose new pathways for the production of known and newly designed compounds. To champion SHIKIFACTORY100 project a consortium with some of the most relevant players in Europe has been assembled, covering research leading institutions in computational design, rapid prototyping and in vivo implementation of pathways and cell factories. As such, six world-leading research partners, four biotechnology SMEs with complementary focus areas and one large industrial company have been integrated. The research partners will be responsible for novel methods for pathway discovery and compound design, collaborating with the SMEs in the implementation and optimisation of the chassis, while SMEs and industrial partners will lead the assessment of the products and the exploitation of the results for different application areas. The industrial partner will be responsible for the validation of the production.

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