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ModelGenomLand

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Modelling the genomic landscapes of selection and speciation

Understanding how natural selection, random genetic drift and demographic events interact to generate and maintain genetic and species diversity has been the central focus of population genetics for many decades. We now have the n... ver más

31/07/2024

UEDIN

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

THE UNIVERSITY OF EDINBURGH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-07-31

ERC-2017-STG: ERC Starting Grant

I+D

Cerrada hace 8 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UEDIN

1.50M€ | Lider

NUEVAS TECNOLOGIAS CIENTIFIC...

1.11M€ | Participante

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Duración del proyecto: 82 meses Fecha Inicio: 2017-09-20
Fecha Fin: 2024-07-31

Líder del proyecto

THE UNIVERSITY OF EDINBURGH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Understanding how natural selection, random genetic drift and demographic events interact to generate and maintain genetic and species diversity has been the central focus of population genetics for many decades. We now have the necessary genome sequence data to make detailed and powerful inferences about the evolutionary past of populations and species, yet our ability to meaningfully interpret such data has remained fundamentally limited. This project will use a combination of theory, development of new inference tools and a large-scale comparative analyses of genome data and has two principal aims: First to develop a general, statistical framework for making inferences about the joint action of past selection and demography from genome sequence data. This will be achieved using analytic calculations and approximations for the joint distribution of linked polymorphic sites. We will use these results to develop new methods to quantify the genome-wide rates of positive and background selection and to scan for genomic outliers of divergence between and positive selection within species. The new methods will be tested using simulations and data from model insects (Drosophila and Heliconius). Second, we will apply the new inference approach to genome data for 20 species pairs of European butterflies and conduct a systematic comparison of the demographic and selective forces involved in speciation. This will reveal how repeatable speciation processes are both in terms of the demographic and selective events, and the genes and genomic architectures involved. Specifically, we will test whether selection during speciation is concentrated at chromosomal rearrangements and/or candidate gene families involved in mate recognition and host plant adaptation. This project will fundamentally improve both our understanding of speciation and selection and our ability to use sequence data to study population processes (be they selection, demography or both) in any system.

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