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Mobilising the enzymatic potential of hydrocarbonoclastic bacteria and the oleag...

Mobilising the enzymatic potential of hydrocarbonoclastic bacteria and the oleaginous yeast Yarrowia lipolytica to create a powerful cellular production platform for lipid derived industrial materials This proposal aims at developing a versatile fermentation platform for the conversion of lipid feed stocks into diverse added-value products. It is proposed to develop the oleaginous yeast Yarrowia lipolytica into a microbial fact... see more

31/07/2011

UGent

1M€

Project Budget: 1M€

Project leader

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 9 Participantes

Financing granted El organismo FP7 notifico la concesión del proyecto The day 2011-07-31 We do not have the information of the call

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

9 Participantes

UGent

0.00€ | Leader

UNIVERSITY OF NAIROBI

INRAE

N.D. | participant

AVECOM

N.D. | participant

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Project leader

UNIVERSITEIT GENT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description This proposal aims at developing a versatile fermentation platform for the conversion of lipid feed stocks into diverse added-value products. It is proposed to develop the oleaginous yeast Yarrowia lipolytica into a microbial factory by directing its versatile lipid metabolism towards the production of industrially valuable compounds like wax esters (WE), polyhydroxyalkanoates (PHA’s), free hydroxyl fatty acids (HFA’s) and isoprenoid-derived compounds (carotenoids, polyenic carotenoid ester). Conversion of lipid intermediates into these products will be achieved by introducing heterologous enzyme functions isolated from marine hydrocarbonoclastic bacteria into Yarrowia. To achieve these goals we have assembled a team with a broad set of complementary expertise in microbial physiology, metabolic engineering, yeast lipid metabolism, metagenomics, biochemical and protein engineering. Already available for this project are a number of genetically engineered Yarrowia strains as well as a collection of genes encoding enzymes for the production of WE’s, 3-HFA’s, PHA’s and carotenoids. The following complementary research focus areas are proposed: (1) Engineering of metabolic precursor pools in Yarrowia lipolytica for the production of added-value products from lipids (INRA, UGe). (2) Conversion of metabolic precursor pools in Yarrowia to added-value products by overexpressing heterologous biosynthetic enzymes (UGe, INRA, UoM). (3) Discovery and characterization of novel aliphatic enzyme activities by metagenomic screening of marine hydrocarbonoclastic and other oil- and fat-metabolizing microbial communities (TUBS, UoN). The project is further complemented by: (i) the activity of a professional valorization company (Ascenion) providing IP protection and commercialization services; (ii) by proactive efforts to expand the project’s target products’ application potential (Avecom).

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