Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MRCA

Financiado

Cerrado

MITOCHONDRIAL RESPIRATORY CHAIN ASSEMBLY

Oxidative phosphorylation (OXPHOS) is the metabolic process that provides most of the energy usable by the cells. OXPHOS couples two sets of reactions, respiration and ATP synthesis. Respiration consists in the sequential transfer... ver más

08/06/2014

Instituto Aragonés...

45K€

Presupuesto del proyecto: 45K€

Líder del proyecto

Instituto Aragonés de Ciencias de la Salud No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 390K€

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-06-08 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

Instituto Aragonés de Cienci...

0.00€ | Lider

UNIZAR

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2012-33516 BASE ESTRUCTURAL DE LA REGULACION DEL GENOMA MITOCONDRIAL 211K€ Cerrado

RESPICHAIN Structure and mechanism of respiratory chain molecular machi... 2M€ Cerrado

RESPARA Impact of mitochondrial respiration efficiency on plant cell... 100K€ Cerrado

PID2019-110320RB-I00 NUEVOS GENES IMPLICADOS EN LA FUNCION OXPHOS: DESARROLLO DE... 97K€ Cerrado

SAF2015-65633-R FISIOPATOLOGIA DEL SISTEMA OXPHOS: GENETICA, AMBIENTE Y META... 508K€ Cerrado

MITO-GARAGE Deciphering the Roles of the Salvage and De Novo Pathways of... 261K€ Cerrado

Líder del proyecto

Instituto Aragonés de Ciencias de la Salud No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 390K€

Presupuesto del proyecto 45K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Oxidative phosphorylation (OXPHOS) is the metabolic process that provides most of the energy usable by the cells. OXPHOS couples two sets of reactions, respiration and ATP synthesis. Respiration consists in the sequential transfer of electrons carried out by the mitochondrial respiratory chain (MRC) complexes I (CI), II (CII), III (CIII), and IV (CIV). The proton gradient generated during respiration is used by the ATP synthase (CV). The components of the OXPHOS system, localized in the inner mitochondrial membrane, are large heteromeric enzymes whose subunits are encoded in two separated genomes, the nuclear and mitochondrial (mt) DNAs. The assembly of these subunits into the complete complexes is an intricate process in which many factors must interplay. In addition, it has been proved that CI, CIII and CIV interact with each other giving rise to supercomplexes (also called respirasomes). It has been determined that many mitochondrial disorders result in an altered assembly of one or several components of the MRC. However, many aspects of the mechanisms underlying the molecular defects in these disorders are still unknown. Therefore, it is necessary to investigate the assembly processes and the involved factors, in order to get a deeper understanding on OXPHOS biogenesis that will shed light on the pathogenetic mechanisms underlying the mitochondrial disorders caused by defective complex assembly. The objectives of the study will be: 1) to determine the entry point of the mtDNA-encoded CI subunits in the assembly process of this complex, which remains to be established; 2) to determine the order of events and the involved factors in the assembly process of human and mouse CIII which has not been studied yet in mammalian systems and 3) to study the factors and processes that determine the interaction between the individual complexes in the formation of the supercomplexes and the physiological relevance of these interactions for the activity of the OXPHOS system.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores