FLUOR-DIOX
Financiado
Migratory 1,n-fluoroalkylcarboxylation of non-activated alkenes via dual photore...
Migratory 1,n-fluoroalkylcarboxylation of non-activated alkenes via dual photoredox/ Nickel catalysis
Catalytic chain-walking reactions have recently emerged as a powerful tool for efficiently introducing functionalities at remote sp3 C–H sites within alkyl side chains. Nevertheless, substantial challenges remain when forging mult...
Catalytic chain-walking reactions have recently emerged as a powerful tool for efficiently introducing functionalities at remote sp3 C–H sites within alkyl side chains. Nevertheless, substantial challenges remain when forging multiple C–C bonds while maintaining a predictable site-selectivity profile in chain-walking scenarios, particularly by controlling both regioselectivity and enantioselectivity. This project will explore the ability to introduce both fluorinated fragments and CO2 at an unsaturated hydrocarbon via dual photoredox/nickel catalysis with a predictable selectivity pattern. Such a transformation constitutes an unrecognized opportunity in chain-walking scenarios for introducing, at will, fluorinated fragments and carboxylic acid functions in a dual, yet modular, site-selective manner. Aimed at exploring the full potential of such an approach for accessing added-value fluoroalkyl carboxylic acids, a new class of C2-symmetric ligands will be rationally designed and developed. The impact that this technique might have in industrial endeavors will be assessed in collaboration with industrial partners of the host group by its application in late-stage modification of advanced intermediates, radiolabeling, and the synthesis of MRI probes.
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Duración del proyecto: 24 meses
Fecha Inicio: 2024-03-06
Fecha Fin: 2026-03-31
Fecha Fin: 2026-03-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-06
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2023-PF-01-01:
MSCA Postdoctoral Fellowships 2023
Cerrada
hace 1 año
Presupuesto
El presupuesto total del proyecto asciende a
181K€
Líder del proyecto
FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMI...
Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion
Perfil tecnológico
TRL
4-5
50K
Perfil tecnológico
TRL
4-5
50K