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Microsatellite Barcoding reconstructing the family tree of hematopoietic cells

While murine hematopoiesis has been considered as resolved science, recent results using barcoding, which allows the tracing of single cells in vivo, clearly show that the topology of the murine hematopoietic tree needs revisions.... ver más

31/07/2024

INSTITUT CURIE FON...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-07-31

ERC-2017-STG: ERC Starting Grant

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Cerrada hace 8 años

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3 Participantes

INSTITUT CURIE FONDATION

1.50M€ | Lider

SIMTE MEDIOAMBIENTE

541.36K€ | Participante

CNRS

345.63K€ | Participante

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Duración del proyecto: 80 meses Fecha Inicio: 2017-11-15
Fecha Fin: 2024-07-31

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto While murine hematopoiesis has been considered as resolved science, recent results using barcoding, which allows the tracing of single cells in vivo, clearly show that the topology of the murine hematopoietic tree needs revisions. In parallel, human hematopoiesis has been overlooked and is widely considered as following the same tree as in mice. To leverage our understanding of normal human hematopoiesis, tools for barcoding in humans are urgently needed. This research program seeks to meet this need by taking advantage of recent developments in next generation sequencing to provide an improved barcoding method for in vivo use in human. Our microsatellite barcoding method exploits the fact that microsatellites in various loci undergo length changes during cell division, to create a natural barcode for each cell, and reconstruct the overall differentiation tree using a phylogenetic algorithm. Our technique, which is highly detailed with respect to current versions of microsatellite barcoding, provides high dimensional characterization of the cells and will allow the inference of important properties such as new phenotypic markers and key molecular regulators. Therefore, we will provide insights into both cell lineage and the molecular mechanisms involved in differentiation. With this method, we will provide the first in vivo description of the human hematopoietic tree and identify new progenitors and key molecular factors involved in human hematopoiesis. This knowledge will allow us to test whether cells with different origins have different functions, a key question in immunology in particular during infection and inflammation, and it will help design ways of therapeutically manipulating the hematopoietic system. More generally it will impact our understanding of stem cell differentiation for which hematopoiesis is used as an exemplar.

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