Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MicroCONtACT

Financiado

Microglial control of neuronal activity in the healthy and the injured brain

Microglia are the main immune cells of the brain, but their role in brain injury is highly controversial due to the difficulties in selectively manipulating and imaging microglial actions in real time. Specifically, it is unclear... ver más

31/03/2023

HUN REN IEM

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

HUN REN KISERLETI ORVOSTUDOMANYI KUTATOINTEZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-03-31

ERC-2016-COG: ERC Consolidator Grant

I+D

Cerrada hace 8 años

0% 100% 100%

2 Participantes

HUN REN IEM

2.00M€ | Lider

COMPUESTOS Y GRANZAS,

576.12K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MICRO-COPS Microglia Control of Physiological Brain States 10M€ Cerrado

AstroScope Mesoscale two-photon imaging of astrocytic calcium dynamics... 173K€ Cerrado

NEoC NEoC – NeuroEnergetics-on-Chip: Disease modeling of impaired... 207K€ Cerrado

ImmunoMet Immunometabolic regulation of microglia function in stroke r... 165K€ Cerrado

PGC2018-094307-B-I00 ALTERACIONES CELULARES Y SINAPTICAS DE LA CORTEZA CEREBRAL E... 303K€ Cerrado

ANCoDy Delineation of experience-dependent astrocyte-neuron cogniti... 231K€ Cerrado

Duración del proyecto: 72 meses Fecha Inicio: 2017-03-24
Fecha Fin: 2023-03-31

Líder del proyecto

HUN REN KISERLETI ORVOSTUDOMANYI KUTATOINTEZ... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Microglia are the main immune cells of the brain, but their role in brain injury is highly controversial due to the difficulties in selectively manipulating and imaging microglial actions in real time. Specifically, it is unclear whether microglia control neuronal survival after injury via shaping the activity of complex neuronal networks in vivo. To this end, we have combined fast in vivo two-photon imaging of neuronal calcium responses with selective microglial manipulation for the first time. Our data suggest that microglia constantly monitor and control neuronal network activity and these actions are essential to limit excitotoxicity and neuronal death after acute brain injury. We also identify microglia as key regulators of spreading depolarization in vivo. However, the underlying mechanisms remained unexplored. Here, I propose that microglia control neuronal excitability and based on preliminary data I set out to investigate how this occurs. We will combine selective, CSF1R-mediated microglia depletion with advanced neurophysiological methods such as in vivo calcium imaging and intracranial EEG for the first time, to reveal how microglia shape activity of complex neuronal networks in the healthy and the injured brain. Then, we will study microglia-neuron interactions from the network level to nanoscale level using in vivo two-photon imaging and super-resolution microscopy. We will apply novel chemogenic and optogenetic approaches to manipulate microglia in real time, assess their role in neuronal activity changes and investigate the molecular mechanisms in vitro and in vivo. Our unpublished data also suggest that inflammation – a key contributor to brain diseases – could disrupt microglia-neuron signaling and we set out to investigate the underlying mechanisms. By using state-of the-art research tools that had not been applied previously in this context, our studies are likely to reveal novel pathophysiological mechanisms relevant for common brain diseases.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores