Microfluidic assisted fabrication of artifical microniches for bone marrow stem...
Microfluidic assisted fabrication of artifical microniches for bone marrow stem cells
There is a growing interest in adult stem cells, especially from bone marrow, for regenerative medicine. Hematopoietic stem cells, a type of bone marrow stem cells, alone cannot be expanded in vitro; in vivo, they reside in a micr...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
ENABLE
Advancing cell based therapies by supporting implant surviva...
2M€
Cerrado
BIOSCENT
BIOactive highly porous and injectable Scaffolds controlling...
8M€
Cerrado
ATLAS
Bioengineered autonomous cell biomaterials devices for gener...
2M€
Cerrado
STUFFOR
Smart acellular scaffolds for bone repair
8K€
Cerrado
STUFFOR
Smart acellular scaffolds for bone repair
173K€
Cerrado
BFU2010-17450
DISEÑO Y PRODUCCION DE PARTICULAS PROTEICAS PARA LA INGENIER...
157K€
Cerrado
Información proyecto MicroNICHE
Duración del proyecto: 46 meses
Fecha Inicio: 2016-04-04
Fecha Fin: 2020-02-26
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
There is a growing interest in adult stem cells, especially from bone marrow, for regenerative medicine. Hematopoietic stem cells, a type of bone marrow stem cells, alone cannot be expanded in vitro; in vivo, they reside in a microenvironment known as a niche that maintains them in a quiescent state until prompted to differentiate. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function. Additionally to regulatory factors in these stem cell niches, a number of environmental and mechanical signals arising from the extracellular matrix are crucial regulators of stem cell fate. In order to expedite for basic studies of bone marrow stem cells, and further translational implementation, any realistic approach to the native stem cell niche requires: to engineer a biomimetic 3D-microenvironment, and then to develop artificial microniches with the key functional features reconstructed. High-throughput microfluidic technology offers high promise, however, adaptation to accommodate adult stem cells in artificially fabricated niches remains still a challenge. Microfluidic-assisted culture systems should not only allow maintaining cell homeostasis through biochemical and mechanical stimulation, but also modulating adult stem cell renewal and differentiation through microscale patterning of cells and extracellular materials in biomimetic microniches. This project aims at the microfluidic reconstruction of an artificial stem cell niches. In this proof-of-concept, a bone marrow stem cell microniche with tunable size, material and topography will be developed by integrating novel fabrication microfluidics with material engineering.