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APROSUS

Financiado

Cerrado

Microbiome-derived asthma and allergy protective substances for prevention

Asthma and allergies are the epidemic of the 21st century after a sharp rise in prevalence since the middle of the last century. Asthma is the most common chronic condition for children – at school age about every 10th pupil is af... ver más

31/12/2027

HMGU

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-10-26

ERC-2021-ADG: ERC ADVANCED GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

HMGU

2.00M€ | Lider

TUM

500.00K€ | Participante

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Duración del proyecto: 62 meses Fecha Inicio: 2022-10-26
Fecha Fin: 2027-12-31

Líder del proyecto

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Asthma and allergies are the epidemic of the 21st century after a sharp rise in prevalence since the middle of the last century. Asthma is the most common chronic condition for children – at school age about every 10th pupil is affected in westernized countries. Likewise, allergic illnesses are very prevalent with 30- 50 % of the paediatric population being affected. Currently, there is neither cure nor effective prevention. However, asthma and allergies are illnesses, which are largely environmentally determined. Exposures to the environmental microbiome greatly determine risk and protection from onset of illness in populations of common genetic make-up. My team and I have described relevant taxa of the environmental microbiome in the unique farm studies we pioneered. Very recently, we discovered the microbiome-derived functional agents conferring protection. These epidemiological findings while being scientifically cutting edge, cannot be back translated to children’s and their families’ benefit. My vision is thus to move the field of microbiome research forward towards in depth characterization of microbe-derived metabolite complexes to better understand their associated asthma- and allergy protective properties by advancing both the experimental and the human population-based studies. The interdisciplinary APROSUS Project addresses this research gap. The aims are to characterize and synthetize these functional agents (aim 1), to understand the underlying mechanisms of protection (aim 2) and to validate the findings in the population-based farm studies (aim 3). Thereby we will lay the ground for translation into innovative and effective prevention strategies to stop the asthma and allergy epidemic.

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