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McGEA

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Metallo enzymes and Cells for Green Environmental Alternatives

"""By far, nature is the best chemist of all time"" according to Nobel Prize winner Frances Arnold. McGEA will develop nature inspired strategies to help avert the pending climate catastrophe. We will discover, characterize, engin... see more

30/11/2028

UNL

1M€

Project Budget: 1M€

Project leader

UNIVERSIDADE NOVA DE LISBOA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-08-01

HORIZON-MSCA-2023-SE-01-01: MSCA Staff Exchanges 2023 Expected Outcome:Project results are expected to contribute to the following outcomes:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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11 Participantes

UNL

372.60K€ | Leader

UNIVERSITY OF NEW MEXICO - U...

ZYMVOL BIOMODELING

78.20K€ | participant

CNRS

138.00K€ | participant

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Project duration: 51 months Date Start: 2024-08-01
End date: 2028-11-30

Project leader

UNIVERSIDADE NOVA DE LISBOA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 1M€

participation deadline Sin fecha límite de participación.

Project description """By far, nature is the best chemist of all time"" according to Nobel Prize winner Frances Arnold. McGEA will develop nature inspired strategies to help avert the pending climate catastrophe. We will discover, characterize, engineer and exploit metalloenzymes as potent biocatalysts to efficiently perform chemically challenging reactions of high environmental impact. Specifically, we will use metalloenzymes to tackle three burning issues that fall squarely in the remit of the EU Green Deal action plan: CO2 capture, (bio)hydrogen production, and wastewater monitoring and remediation. These challenges will be addressed using purified metalloenzymes incorporated into hybrid materials and live bacterial cells as self-regenerating catalytic metalloenzyme carriers. Implementation of these two strategies will proceed with research activities across the full pipeline of metalloenzyme development. This will include i) the assembly of the metallic co-factors, as a prerequisite for establishing protocols for efficient metalloenzyme production, ii) rational redesign, directed evolution and in silico strategies to develop enzyme variants that show improved catalytic activity and stability, and iii) the incorporation of the enzymes into matrices that allow for enzyme reusability, stabilization, or their self-assembly into multi-enzymatic nanostructures for substrate channeling. The execution of this program relies on a strong interdisciplinary and intersectoral team. The McGEA brings together 6 research groups from EU and 2 research groups from overseas, all of them internationally recognized for their scientific excellence, and 3 EU companies that will join forces to accelerate the transition to a climate-neutral Europe. The consortium is designed to provide a diverse portfolio of skills through staff secondments to achieve integration from the stages of fundamental scientific discovery to the development of metalloenzyme-based processes and prototype devices."

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