Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

METABOLATE

Financiado

METABOLic immuno-engineered biomATErials

Large bone defects display compromised healing associated with pronounced inflammation and constitute a major clinical problem. Recently, a range of novel biomaterial-based approaches have been engineered to promote bone regenerat... ver más

20/07/2025

ROYAL COLLEGE OF S...

242K€

Presupuesto del proyecto: 242K€

Líder del proyecto

ROYAL COLLEGE OF SURGEONS IN IRELAND No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-09

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

0% 100% 100%

3 Participantes

ROYAL COLLEGE OF SURGEONS IN...

242.48K€ | Lider

TRINITY COLLEGE DUBLIN

N.D. | Participante

TAMIRNA

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

DPI2010-20399-C04-03 DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAF... 208K€ Cerrado

RTI2018-096088-J-I00 MATRICES TERAPEUTICAS IMPRESAS EN 3D BASADAS EN SILICE QUE M... 157K€ Cerrado

MACxercise Dissecting Macrophage Mechanobiology to Engineer Immuno-Rege... 1M€ Cerrado

BES-2011-046144 DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAF... 43K€ Cerrado

MAT2015-68906-R DESARROLLO DE PARTICULAS POLIMERICAS PARA GENERAR MATRICES E... 242K€ Cerrado

DPI2010-20399-C04-01 DISEÑO, CONSTRUCCION Y VALIDACION DE UNA PLATAFORMA BIOMIMET... 188K€ Cerrado

Duración del proyecto: 28 meses Fecha Inicio: 2023-03-09
Fecha Fin: 2025-07-20

Líder del proyecto

ROYAL COLLEGE OF SURGEONS IN IRELAND No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 242K€

Descripción del proyecto Large bone defects display compromised healing associated with pronounced inflammation and constitute a major clinical problem. Recently, a range of novel biomaterial-based approaches have been engineered to promote bone regeneration. However, once these constructs are implanted, they encounter the harsh environment of damaged tissue and often fail to induce a regenerative response. With this MSCA Post-Doctoral Fellowship, I will address the clinical problem of large bone defect repair by harnessing extracellular vesicles (EVs) derived from metabolically modulated macrophages to promote the immunogenic, angiogenic, and osteogenic response in the long-term healing cascade. Specifically, my research goal is to generate an immuno-engineered scaffold with these multitargeted regenerative EVs to maximise bone repair. The proposed multidisciplinary project will be carried out in the Tissue Engineering Research Group (TERG) at the Royal College of Surgeons in Ireland (RCSI), which is a leading partner in the Science Foundation Ireland (SFI) funded Advanced Materials and BioEngineering Research Centre (AMBER) under the supervision of Prof. Annie Curtis. Additionally, as part of my project training plan, I will carry out a secondment in Trinity College Dublin, under the supervision of Prof. David Hoey, gaining expertise in materials for bone regeneration. At the end of the fellowship, with my non-academic placement at TAmiRNA, a biotech company specialising in diagnostic and therapeutic miRNAs, I will investigate the small RNA-cargo of the pro-regenerative EVs for the identification of new specific therapeutic targets. METABOLATE is a unique opportunity to acquire advanced research competencies and complementary skills through interdisciplinary and inter-sectoral training. This will allow me to mature as an independent scientist and to enrich my professional profile, preparing me for a multitude of career choices.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores