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MELANOPSIN CONTRIBUTION TO PATTERNS DISCIRMINATION IN DIURNAL AND NOCTURNAL RODE...

MELANOPSIN CONTRIBUTION TO PATTERNS DISCIRMINATION IN DIURNAL AND NOCTURNAL RODENTS Three types of retinal photoreceptors are responsible for light detection: rods, cones and intrinsically photosensitive retinal ganglion cells (ipRGCs) containing melanopsin. Until recently, it was universally assumed that daytime... ver más

01/09/2022

UNIVERSITY OF MANC...

225K€

Presupuesto del proyecto: 225K€

Líder del proyecto

THE UNIVERSITY OF MANCHESTER No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-09-01

MSCA-IF-2019: Individual Fellowships

I+D

Cerrada hace 5 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVERSITY OF MANCHESTER

224.93K€ | Lider

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Duración del proyecto: 28 meses Fecha Inicio: 2020-04-09
Fecha Fin: 2022-09-01

Líder del proyecto

THE UNIVERSITY OF MANCHESTER No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 225K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Three types of retinal photoreceptors are responsible for light detection: rods, cones and intrinsically photosensitive retinal ganglion cells (ipRGCs) containing melanopsin. Until recently, it was universally assumed that daytime vision originates with cones, dim light vision with rods, leaving ipRGCs to drive sub-conscious reflex responses to changes in ambient light (e.g. circadian photoentraiment). However, very recent data from mice has revolutionized vision science by showing that melanopsin can also provide the brain with information about the spatial patterns during the day, complementing the activity of cones in the representation of larger amplitude and coarser patterns in brightness. The proposed project is aimed to determine how melanopsin and cones work together to create images in nocturnal mice and in a diurnal murid (Rhabdomys) with strong cone-based daytime vision, respectively. We will take advantage of technological edge in multi-primary visual display (mVDU) design that allows, for the first time, patterns visible only to melanopsin to be generated. We will apply the mVDU technology to in vivo multi-unit electrophysiological recordings from the visual thalamus (the dorsal lateral geniculate nucleus) and behavioural experiments on melanopsin sufficient and deficient mice created by optogenetical manipulation of ipRGCs. We hypothesize that there will be significant differences in the melanopsin contribution to pattern discrimination between chosen night and day active animals due to the difference in their retinal structure (rod-cone ratio). We believe that the proposed research will contribute to better understanding of the visual system and lead to a step change in performance of image capture and display technologies by adjusting their design to take account of melanopsin. The applicant will benefit from the project with new skills, knowledge and the experience to launch her own research group in the future.

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