Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MicroSynCom

Financiado

Cerrado

Mechanisms of Microglia Synapse Communication

Microglia are the resident tissue macrophages of the brain and represent cells of the innate immune system. Looking at microglia from the immunological perspective, much is known about their role during inflammatory processes, fac... ver más

31/08/2025

BUNDESMINISTERIUM...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

BUNDESMINISTERIUM FUER GESUNDHEIT No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-02-25

ERC-2019-COG: ERC Consolidator Grant

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

BUNDESMINISTERIUM FUER GESUN...

1.69M€ | Lider

EUROPEA DE HINCAS TELEDIRIGI...

572.22K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

LIPSYNING Eat me microglia lipid scrambling as a signal for synaptic... 131K€ Cerrado

MICRO-COPS Microglia Control of Physiological Brain States 10M€ Cerrado

SinGly Glycobiology of synaptic pruning in a developing brain 146K€ Cerrado

SYNSIGNAL Molecular signals for synaptic pruning by microglia 180K€ Cerrado

MG interactions Towards understanding neuron microglia communication in the... 162K€ Cerrado

MICROGLIA-CIRCUIT Microglia action towards neuronal circuit formation and func... 2M€ Cerrado

Duración del proyecto: 66 meses Fecha Inicio: 2020-02-25
Fecha Fin: 2025-08-31

Líder del proyecto

BUNDESMINISTERIUM FUER GESUNDHEIT No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Microglia are the resident tissue macrophages of the brain and represent cells of the innate immune system. Looking at microglia from the immunological perspective, much is known about their role during inflammatory processes, factors that activate them and how they response e.g by releasing cytokines to mount an inflammatory response. This response has been shown to be detrimental during disease processes and lead to pruning/loss of synapses, a task microglia carry out also during development. Although microglia obviously play an important role in synaptic pruning and loss, it remains an open question, whether microglia are involved in the process of synapse formation under physiologic conditions. Therefore, the main hypothesis of MicroSynCom is that microglia represent the mediator of synapse formation or linker between pre- and post-synapse: sensing neurotransmitter release at highly active pre-synaptic sites and actively orchestrating the formation of new spines from the dendrite. I propose to investigate and reveal the underlying mechanisms of this tripartite microglia synapse communication process. Therefore, we will use two-photon stimulated emission depletion microscopy (2P-STED), novel viral and genetically encoded sensors for neurotransmitters, as well as optogenetic and chemogenetic manipulation tools. These methods will be combined with behavior test in freely moving, but also head-fixed mice to visualize microglia mediated synapse formation in awake mice. This will allow us for the first time to visualize, investigate and reveal the mechanisms establishing this novel role of microglia as the mediator of synapse formation in life animals and relate it to physiologically relevant neuronal network rewiring.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores