Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MitErrA

Financiado

Mechanisms of cellular response to errors in mitosis: a new, non-genetic approa...

Mechanisms of cellular response to errors in mitosis: a new, non-genetic approach to an old question One of the holy grails in cancer biology is to understand how genomic instability, a hallmark source of mutagenesis, arises. However, surprisingly little is known about non-genetic drivers of tumorigenesis. My proposal will delve... ver más

30/06/2029

IMB

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH No se ha especificado una descripción o un objeto social para esta compañía.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-02-27

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

1 Participantes

IMB

1.50M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BFU2016-75058-P TRANSCRIPTION Y REPLICATION COMO FUENTES DE INESTABILIDAD GE... 484K€ Cerrado

BFU2013-43766-P MECANISMOS IMPLICADOS EN EL MANTENIMIENTO DE LA INTEGRIDAD D... 169K€ Cerrado

TARLOOP R loops as a major modulator of transcription associated rec... 2M€ Cerrado

BFU2017-90889-REDT DINAMICA Y ESTABILIDAD CROMOSOMICA 8K€ Cerrado

PID2020-116003GB-I00 GENOMICA AVANZADA PARA EL ESTUDIO DE LA INTEGRIDAD DE CROMOS... 272K€ Cerrado

BFU2012-30724 REGULACION EPIGENETICA DE LAS FUNCIONES DE LA CROMATINA 468K€ Cerrado

Duración del proyecto: 64 meses Fecha Inicio: 2024-02-27
Fecha Fin: 2029-06-30

Líder del proyecto

INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 1M€

Descripción del proyecto One of the holy grails in cancer biology is to understand how genomic instability, a hallmark source of mutagenesis, arises. However, surprisingly little is known about non-genetic drivers of tumorigenesis. My proposal will delve into the old question of how Mitotic Errors and nuclear Abnormalities (MitErrA) affect cellular homeostasis, from a fresh perspective: the elucidation of non-genetic effects on genome function and cellular adaptation. I recently discovered that micronuclei, a prominent type of errors in mitosis, are a previously unappreciated source of epigenetic instability. This discovery, together with the novel technologies that I developed, will serve as the springboard to address four fundamental questions: 1) How is chromatin state affected in abnormally segregated chromosomes? 2) What are the mechanisms of transcriptional (dys)regulation following errors in mitosis? 3) How is genome organization perturbed in imbalanced genomes? 4) What is the physiological significance of abnormal chromosomes generated by mitotic errors? I will combine cutting edge techniques, such as targeted chromosome manipulation and single-cell genomics, with advanced systems to track mis-segregated chromosomes by live-cell imaging over multiple generations. I will identify additional sources of inherited abnormal nuclear structures (termed Mit-bodies) and characterize their DNA damage/repair dynamics and epigenetic alterations. I will study how transcription dynamics are perturbed in daughter cells upon abnormal mitosis and define higher-order genome organization, nuclear positioning and lamina association of mis-segregated chromosomes. Finally, I will investigate long-term cellular adaptations and assess the tumorigenic potential of these abnormal chromosomes. Altogether, these studies will offer the first comprehensive assessment of the non-genetic mechanisms by which errors in mitosis may drive cellular adaptation and tumorigenesis.

Conecta tu I+D

Entra hoy

¿Olvide mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores