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GLYCANC

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Matrix glycans as multifunctional pathogenesis factors and therapeutic targets i...

Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also with... see more

30/06/2019

567K€

Project Budget: 567K€

Project leader

UNIVERSITAET MUENSTER No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 16 Participantes

Financing granted El organismo H2020 notifico la concesión del proyecto The day 2019-06-30

MSCA-RISE-2014: Marie Skłodowska-Curie Research and... Scope:Objective:

I+D

Cerrada does 11 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

16 Participantes

103.50K€ | Leader

45.00K€ | participant

CAIRO UNIVERSITY

SERENDIP GMBH

4.50K€ | participant

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Project duration: 55 months Date Start: 2014-11-25
End date: 2019-06-30

Project leader

UNIVERSITAET MUENSTER No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 567K€

participation deadline Sin fecha límite de participación.

Project description Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.

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