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Mathematical Optimization for clinical DEcision Support and Training

Physicians need to make many important decisions per day. One clinical example is the scheduling and dosage of chemotherapy treatments. A second example is the discrimination of atrial fibrillation from atypical atrial flutter, ba... ver más

30/06/2020

OVGU

2M€

Presupuesto del proyecto: 2M€

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OTTOVONGUERICKEUNIVERSITAET MAGDEBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-06-30

ERC-CoG-2014: ERC Consolidator Grant Scope:Objectives

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2 Participantes

OVGU

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IDEAS Y DESARROLLO PARA LA M...

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Duración del proyecto: 62 meses Fecha Inicio: 2015-04-09
Fecha Fin: 2020-06-30

Líder del proyecto

OTTOVONGUERICKEUNIVERSITAET MAGDEBURG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Physicians need to make many important decisions per day. One clinical example is the scheduling and dosage of chemotherapy treatments. A second example is the discrimination of atrial fibrillation from atypical atrial flutter, based on ECG data. Such important and complex decisions are usually based on expert knowledge, accumulated throughout the life of a physician and shaped by subjective (and sometimes unconscious) experience. It is not readily transferable and may be unavailable in rural areas. At the same time, the available imaging, laboratory, and basic clinical data is abundant and waits to be used. This data is not yet systematically integrated and often single data-points are used to make therapy decisions. More and more clinical decision making tasks will be modeled in terms of mathematical relations. I propose a systematic approach that supports and trains individual decision making. The developed ideas, mathematical models, and optimization algorithms will be generic and widely applicable in medicine and beyond, but also exploit specific structures, resulting in a patient- and circumstance-specific personalized medicine. This allows, e.g., a physician to first simulate the impact of his decisions on a computer and to consider optimized solutions. In the future, it will be the rare and unwanted exception that an important decision can not be backed up by consultation of a model-driven decision support system or based upon a systematic model-driven training. MODEST has a mathematical core. It builds on a comprehensive, interdisciplinary work program, based on disciplinary expertise in mixed-integer optimal control and existing collaborations with medical and educational experts. It is both timely, given the increasing availability of data and the maturity of mathematical methods, models, and software; as well as high-impact, due to the large number of clinical areas that may benefit from optimization-based decision support and training tools.

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