Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

CANCERSYS

Financiado

Cerrado

Mathematical modelling of beta catenin and ras signalling in liver and its impac...

Mathematical modelling of beta catenin and ras signalling in liver and its impact on proliferation tissue organization and formation of hepatocellular carcinomas The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linki... ver más

31/10/2011

IFADO

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 9 Participantes

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-10-31 No tenemos la información de la convocatoria

0% 75% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

9 Participantes

IFADO

0.00€ | Lider

CHARITE UNIVERSITAETSMEDIZI...

N.D. | Participante

Proyectos interesantes

Cells2Tissues

Medical Technol...

Data Science

3M€ Cerrado

HeteroCancerInvasion

Medical Technol...

Data Science

195K€ Cerrado

BES-2010-030056

Medical Technol...

Data Science

43K€ Cerrado

SPATONC

Medical Technol...

Data Science

2M€ Cerrado

APOQUANT

Medical Technol...

Data Science

1M€ Cerrado

MTM2009-13832

Medical Technol...

Data Science

123K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Líder del proyecto

FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linking measurements in primary heptocytes with effects at the organ level will address the impact of these signalling networks on proliferation, tissue organization and formation of hepatocellular carcinoma. In a close collaboration of scientists from theoretical fields and life sciences, our approach will combine dynamic modelling of signalling networks with spatial-temporal modelling of the liver microarchitecture. For this purpose dynamic models of the beta-catenin and ras core modules and their interactions will be integrated into a single-cell based three-dimensional model of the liver lobule. This model will be used to predict the impact of beta-catenin and ras activation on tissue organization starting with the early events, such as enhanced proliferation as well as micromotility of single cells, followed by formation of nodules and finally of dedifferentiated hepatocarcinomas. Predictions obtained by the model will be validated by inducible Apclox/lox and Ha-rasQ61R mouse strains, which have already been established by members of our consortium and allow induction of hepatocellular carcinoma. In addition the model predictions of the combined influence of active beta-catenin and ras signalling will be validated using a mouse strain that allows induction of both pathways in hepatocytes. In an iterative process, the model will be validated and adjusted to the in vivo situation. The model aims at the identification of systems properties of beta-catenin and ras signalling exploited during carcinogenesis and will foster the prediction of strategies for effective intervention, thereby facilitating the design of novel therapeutic strategies to combat hepatocellular carcinoma.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores