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MAREP

Financiado

Cerrado

MAssive intracellular REcording for Pharmacology

Due to the vital role of the heart, cardiac safety assessment has become one of the major gatekeepers in all stages of the drug development process, increasing costs and resources required for new drugs. Despite the recent advance... ver más

30/04/2021

IIT

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-04-30

ERC-2019-POC: ERC Proof of Concept Grant

I+D

Cerrada hace 6 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

IIT

150.00K€ | Lider

TECNOLOGIA DE CORTE E INGENI...

788.35K€ | Participante

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Duración del proyecto: 21 meses Fecha Inicio: 2019-07-02
Fecha Fin: 2021-04-30

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Due to the vital role of the heart, cardiac safety assessment has become one of the major gatekeepers in all stages of the drug development process, increasing costs and resources required for new drugs. Despite the recent advancements of the Comprehensive In vitro ProArrhythmia (CiPA) initiative, there are still important obstacles related to chronic cardiotoxicities and to unreliable cell models. Thus, there is a strong need for new solutions that can improve the efficacy of drug development processes. The MAREP project aims at tackling this problem by demonstrating a novel automated system for the comprehensive pharmacologic investigation of drug effects on in-vitro cardiac cell cultures. The novel approach combines laser excitation of novel metamaterials with high density multielectrode arrays (HD-MEA), providing high quality and high throughput recording of cardiac cells activity and offering an unprecedented and affordable method for the global study of drug effects on the heart. The outcome of the project is the prototype of a system that combines electrical recording of action potentials of thousands of cardiac cells with laser-based cell poration and intracellular recording. In essence, cardiac cells can be investigated in physiological conditions while drugs are administered and their effects studied in details on a large and reliable biological sample. The MAREP technology will boost the development of new drugs through the establishment of a novel, affordable, cost-effective and automated experimental procedure. This project intends to exploit a research innovation born, though not exploited, in the parent ERC project Neuro-plasmonics. This innovation may bring the laser-based bio-nanotechnologies developed in Neuro-plasmonics closer to commercialization by introducing a novel interface that is fully compatible with standard CMOS technology and with large scale production.

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