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AxoBrain

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Mapping the axolotl brain and its regeneration

The Axolotl is an extraordinary model system to study regeneration in tetrapods. Remarkably, the axolotl is able to regenerate parts of the brain after major injury, however the molecular mechanisms that orchestrate regeneration a... see more

31/03/2030

IMBA

9M€

Project Budget: 9M€

Project leader

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-03-21

ERC-2023-SyG: ERC Synergy Grants Objective:The aim is to provide support for a small group of two to four Principal Investigators to...

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

IMBA

3.00M€ | Leader

ETH Zürich

3.00M€ | participant

MPG

2.94M€ | participant

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Project duration: 72 months Date Start: 2024-03-21
End date: 2030-03-31

Project leader

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 9M€

participation deadline Sin fecha límite de participación.

Project description The Axolotl is an extraordinary model system to study regeneration in tetrapods. Remarkably, the axolotl is able to regenerate parts of the brain after major injury, however the molecular mechanisms that orchestrate regeneration are unclear, and the completeness of functional circuit and behavioral recovery is unknown. Our vision is to develop the axolotl model system to rigorously study central nervous system regeneration, and use discoveries from the axolotl to design novel strategies for regenerating mammalian tissues. The mapping of brain cell types and connections in the axolotl will also have a profound impact on the understanding of vertebrate brain organization and evolution. In AxoBrain, we will integrate scale-crossing technologies to map the axolotl brain at molecular, cellular and circuit resolution, and establish assays to understand how brain cells respond to damage and behavioral circuits regenerate. Our project will be achieved through the following objectives: 1) We will generate a spatiotemporal multiomic atlas of the axolotl brain at single cell resolution. 2) We will generate a connectome of the axolotl retino-tectal-hindbrain circuit and develop behavioral and circuit functional assays in response to visual stimulation. 3) We will establish injury assays and assess regeneration through behavioral, connectomic and single-cell multiomic analysis. 4) Finally, we will apply CRISPR perturbation screens with single-cell genomic readout in vivo and in vitro to identify modulators of regeneration. AxoBrain utilizes quantitative and state-of-the-art methods to explore how the axolotl can regenerate neural circuitry after injury. We have assembled a team with synergistic skill sets that will be required to achieve our vision. This project is a groundbreaking starting point to rigorously investigate how mammals have lost regeneration capabilities over evolution, and will serve as a springboard to design novel strategies for regenerating

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