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Magnetically Tunable Chondrocyte Cell Sheet Engineering for Osteoarthritis Thera...

Magnetically Tunable Chondrocyte Cell Sheet Engineering for Osteoarthritis Therapy Osteoarthritis (OA) is a disease that gradually degrades the cartilage joints, affecting more than 50 million people in Europe. With no known treatment, this population is at risk of lower quality of life and permanent disability.... ver más

31/08/2025

TUM

217K€

Presupuesto del proyecto: 217K€

Líder del proyecto

TECHNISCHE UNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-10

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2024 ExpectedOutcome:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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2 Participantes

TUM

217.31K€ | Lider

CO.DON AG

N.D. | Participante

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Duración del proyecto: 36 meses Fecha Inicio: 2022-08-10
Fecha Fin: 2025-08-31

Líder del proyecto

TECHNISCHE UNIVERSITAET MUENCHEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 217K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Osteoarthritis (OA) is a disease that gradually degrades the cartilage joints, affecting more than 50 million people in Europe. With no known treatment, this population is at risk of lower quality of life and permanent disability. The chondrocyte is a native cell in the cartilage joints that has been studied as a promising cell therapy agent for early-stage OA. Recently, by using a stimuli-responsive (SR) culture plate, many cell types can be prepared as a sheet-like cluster (cell sheet) analogous to the native biological tissue, entailing the enhanced regenerative efficacy when used as cell therapy. However, it is challenging to prepare the chondrocyte cell sheet, as the chondrocyte gradually loses the cartilage feature upon being cultured on the stiff SR plate. In this project, I aim to prepare the cartilage-like chondrocyte cell sheet by developing an innovative technique that is premised on the tuning of substrate stiffness during the cell culture stage. I will focus on three objectives: (1) to develop a new cell sheet-fabrication substrate that has the magnetically tunable stiffness, (2) to study the proof-of-concept of the tunable stiffness technique for modifying the model cell sheet activities, and (3) to apply this dynamic technique to obtain the cartilage-like chondrocyte cell sheet of which its regenerative efficacy against early-stage OA will be evaluated. To perform this project, I will draw from and extend upon my current expertise and works in biomaterial development and stiffness-cell interaction, with that of academic host Prof. Berensmeier (magnetic nanotechnology) and of industrial partner Dr. Vonk (cartilage cell therapy). This synergized academic-industry partnership will continue to the non-academic placement, wherein I will undertake the next-stage preclinical developments of chondrocyte cell sheets in a deeper and more relevant context of OA treatment. The proposed project gives a great contribution to the OA-stricken European society.

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