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LONGSENSE

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LONGSENSE A novel biosensor for lncRNA

The function of ribonucleic acid (RNA) was long thought to be only an intermediate product in the protein synthesis machinery, but this view changed since the biological significance of the non-coding protein fraction of RNA was d... ver más

31/12/2021

TECHNISCHE UNIVERS...

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

TECHNISCHE UNIVERSITAT DARMSTADT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-12-31

ERC-2020-POC: Call for proposals for ERC Proof of...

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2 Participantes

TECHNISCHE UNIVERSITAT DARMS...

150.00K€ | Lider

INDUSTRIAS NAVARRAS DE PRECI...

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Duración del proyecto: 18 meses Fecha Inicio: 2020-06-23
Fecha Fin: 2021-12-31

Líder del proyecto

TECHNISCHE UNIVERSITAT DARMSTADT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The function of ribonucleic acid (RNA) was long thought to be only an intermediate product in the protein synthesis machinery, but this view changed since the biological significance of the non-coding protein fraction of RNA was discovered. More recently a still evolving class of RNAs with a length above 200 nucleotides, the long non-coding RNAs (lncRNA) came into the spotlight. Up- or downregulation have been associated with human diseases, such as neurodegenerative and psychiatric diseases, cardiac diseases, diabetes as well as cancer, offering the possibility to use lncRNA as biomarker for diagnosis and prognosis. The currently used method for lncRNA detection is complicated and only a reliable method for an experienced researcher with the necessary lab facilities. Detection of lncRNA follows a time-consuming protocol, taking at least 1 day from sample preparation to analysed data. To exploit the full potential of lncRNA as new biomarker for several diseases, the detection method needs to be simplified. This would allow to use lncRNA as biomarker on-spot in private praxis and integrate lncRNA in the routine diagnostic of clinics. LONGSENSE will develop a fast, user-friendly and cost-effective biosensor for lncRNA detection. The use of computer modelling for molecular reactions and RNA structure, will enable us to work efficiently and remain flexible to the rapid development in the scientific field and adapt a product to meet the needs of the market. The aims of the project are to (1) create a multi-level biosensor for the detection of disease relevant lncRNA in well-plate format for high throughput screening to be used in clinical labs or research; (2) design a device to be used on the spot; (3) asses the commercial feasibility of the technology.

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