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BIOLOCHANICS

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Localization in biomechanics and mechanobiology of aneurysms Towards personaliz...

Localization in biomechanics and mechanobiology of aneurysms Towards personalized medicine Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties o... ver más

31/12/2020

ARMINES

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-12-31

ERC-CoG-2014: ERC Consolidator Grant

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Cerrada hace 10 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

4 Participantes

ARMINES

1.92M€ | Lider

RECONVERSION Y MANTENIMIENTO...

INSTITUT MINESTELECOM

485.01K€ | Participante

CHU SAINT-ETIENNE

79.39K€ | Participante

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Duración del proyecto: 68 meses Fecha Inicio: 2015-04-22
Fecha Fin: 2020-12-31

Líder del proyecto

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.

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