Innovating Works

InjectCHA

Financiado
Local delivery of PTH 1 34 from an injectable collagen hydroxyapatite scaffold...
Local delivery of PTH 1 34 from an injectable collagen hydroxyapatite scaffold for non invasive treatment of bisphosphonate associated atypical femoral fractures Having recently returned to the EU following Postdoctoral training in Australia, I hope to work as a MSCA Reintegration Fellow to tackle a devastating clinical orthopaedic challenge for which there is currently no effective treatm... Having recently returned to the EU following Postdoctoral training in Australia, I hope to work as a MSCA Reintegration Fellow to tackle a devastating clinical orthopaedic challenge for which there is currently no effective treatment. Specifically, bisphosphonate (BP) associated atypical femoral fractures (AFFs) in osteoporotic patients which are associated with excruciating pain and high levels of morbidity and mortality. The scientific goal of this proposal is to integrate my tools in bone tissue engineering with the advanced drug delivery expertise of Prof. David Brayden’s group at University College Dublin (UCD) to develop a novel injectable therapeutic scaffold as a non-invasive treatment for AFFs. This proposal outlines an innovative research project that aims to implement a revolutionary strategy utilising Teriparatide (PTH-(1-34)) to target BP remobilisation away from AFF site and induce bone repair. In addition, a tissue engineering strategy will be employed that combines a regenerative, load bearing biomaterial for controlled local delivery of PTH(1-34) as a pioneering advance for AFF treatment. As a newly appointed academic, the training objective of this grant is to attain the requisite scientific and complementary skills to successfully develop an independent research programme. This will be achieved through the expert supervision and input of Prof. Brayden and backed up by colleagues in the lab and UCD staff training activities. In addition, by managing the project, I will further develop skills relating to planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also avail of opportunities to recruit and supervise students on this project or related works. In summary, this grant will provide invaluable help to establish an independent research niche in active and emerging research fields, while equipping me with the skills needed as a newly appointed lecturer embarking on an independent research career. ver más
02/05/2019
ROYAL COLLEGE OF S...
176K€
Duración del proyecto: 36 meses Fecha Inicio: 2016-04-25
Fecha Fin: 2019-05-02

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2019-05-02
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2015-EF: Marie Skłodowska-Curie Individual Fellowships (IF-EF)
Cerrada hace 9 años
Presupuesto El presupuesto total del proyecto asciende a 176K€
Líder del proyecto
ROYAL COLLEGE OF SURGEONS IN IRELAND No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5