Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

PROPITIOUS

Financiado

Liquid liquid phase separation mediated protein fibrillation leading to neurodeg...

Liquid liquid phase separation mediated protein fibrillation leading to neurodegenerative diseases Neurodegenerative disorders are the leading cause of physical and cognitive disability, currently affecting ~15% population worldwide with estimated global cost of healthcare accosiated with them expected to at least double in the... ver más

31/05/2027

171K€

Presupuesto del proyecto: 171K€

Líder del proyecto

UNIVERZA V MARIBORU No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-12

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

171.40K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

Tau DG RT-imaging Real-time imaging and mechanistic analysis of Tau fibril dis... 174K€ Cerrado

IDP Assembly Novel Integrated Approach for Assembly Analysis of Intrinsic... 215K€ Cerrado

CNS2023-144437 Biología molecular y celular 194K€ Cerrado

FLUBIODEM Fluid Biomarkers for Neurodegenerative Dementias 2M€ Cerrado

UNDERPIN Untranslated regions of RNAs and protein networks in patholo... 173K€ Cerrado

HUNTING-BrainFibrils Ultrastructural analysis of mutant Huntingtin fibrils extrac... 174K€ Cerrado

Duración del proyecto: 36 meses Fecha Inicio: 2024-05-12
Fecha Fin: 2027-05-31

Líder del proyecto

UNIVERZA V MARIBORU No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 171K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Neurodegenerative disorders are the leading cause of physical and cognitive disability, currently affecting ~15% population worldwide with estimated global cost of healthcare accosiated with them expected to at least double in the next 20 years. Five most common neurodegenerative diseases, including ALS and FTD, are linked to formation of protein deposits in patient tissues and are currently without treatment options that would prevent or alter the disease progression. ALS and FTD pathology is characterised by accumulation and formation of insoluble protein deposits formed by proteins, like TDP-43, FUS and DAXX. These proteins undergo liquid-liquid phase transition (LLPS) in cells forming non-membrane bound organelles, which are important in RNA processing and stress responses of cells but their dysregulation acts a precursor to protein fibrillation. In this project we will, therefore, combine traditional biophysical approaches with modern molecular dynamics simulations and solution state nuclear magnetic resonance to discern this complex behaviour leading to LLPS, and gain molecular insight into its onset. Major outcomes of the project are (1) Develop the necessary simulation tools by reparametrizing currently available force fields using experimental data; (2) Apply the simulation tool and analytical methods to interactions between oligonucleotides and ions with proteins and compare results to experimental data; (3) Map phases and coacervation of DAXX in the presence of nucleotides and ions; (4) identify residues crucial for fibrillation and determine their role in cellular LLPS; (5) Apply high-throughput virtual screening to design proteins aggregation breaking ligands with therapeutic potential Outcomes of this project will importantly enhance our understanding at a mechanistic level, the role of these factors in promoting LLPS in cell biology.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores