Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

HAPLOTAGGING

Financiado

Cerrado

Linking genome variation with haplotype-resolved sequencing

DNA sequencing has transformed biological research, and is fast becoming the standard-of-care in medicine. Chances are good that every European person born today may have their genome sequenced at some point in their lifetime (it... ver más

31/10/2023

MPG

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-31

ERC-2022-POC1: ERC PROOF OF CONCEPT GRANTS1 Objective:Objectives:

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MPG

150.00K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CELL-O-MATIC High Throughput Systematic Single Cell Genomics using Micro... 8M€ Cerrado

UNSE15-CE-3131 Infraestructuras del IBIS. Secuenciacion Masiva 146K€ Cerrado

HAP-PHEN From haplotype to phenotype a systems integration of alleli... 2M€ Cerrado

FLUOROCODE FLUOROCODE a super resolution optical map of DNA 2M€ Cerrado

DIGITAL SEQUENCING Massive Digital sequencing by binary DNA 5M€ Cerrado

EQC2019-005592-P Plataforma de Secuenciación de Célula Única de Alto Rendimie... 155K€ Cerrado

Duración del proyecto: 18 meses Fecha Inicio: 2022-04-28
Fecha Fin: 2023-10-31

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto DNA sequencing has transformed biological research, and is fast becoming the standard-of-care in medicine. Chances are good that every European person born today may have their genome sequenced at some point in their lifetime (it is already happening in Iceland). The currently prevailing sequencing platform, Illumina short-read sequencing, prioritizes content (DNA basepairs) over preserving long-range haplotype context. This decision has paid off so far, but comes at the cost of complicated analyses and often lead to undetected disease-causing chromosome rearrangements. Alternative long-read technologies, however, have yet to deliver the scale and throughput to truly take over from Illumina sequencing. To meet the grand challenge of sequencing humanity and biodiversity, we need both content and context. As part of our ERC StG action, we have invented haplotagging, a technique that restores haplotype context while integrating seamlessly into Illumina sequencing. We have previously published a small-scale pilot study that haplotagging can deliver superior results at a fraction of existing costs. In doing so our team have solved a series of molecular engineering and computational challenges that have stumped far larger parties. However, our prototype dataset are still not large enough to fully allay concerns from potential licensees regarding robust scalability. Thus, we propose to generate a mid-scale, 2000-sample pilot with direct support from Illumina to provide additional benchmark data, guide scale-up efforts and inform decision-making by industry and academic stakeholders. We expect this proposal will help transition haplotagging from a research concept towards the market.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores