Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

LightCas

Financiado

Cerrado

Light controlled synthetic enzyme cascades

There is an urgent need for the development of greener syntheses procedures if mankind wants to maintain an environment worth living in but is at the same time unwilling to accept a reduction in material comfort. The establishment... ver más

30/06/2023

FZJ

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

FORSCHUNGSZENTRUM JULICH GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2023-06-30

ERC-2017-STG: ERC Starting Grant

I+D

Cerrada hace 8 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

FZJ

1.50M€ | Lider

NORTEN PREFABRICADOS DE HORM...

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

INTERfaces Heterogenous biocatalytic reaction cascades training network 4M€ Cerrado

CTQ2011-24237 PREPARACION DE COMPUESTOS ENANTIOENRIQUECIDOS DE GRAN INTERE... 217K€ Cerrado

PID2020-113351RA-I00 SINTESIS SOSTENIBLE DE PRODUCTOS DE INTERES INDUSTRIAL MEDIA... 85K€ Cerrado

EEBB-I-12-04845 QUIMICA SOSTENIBLE. PROCESOS BIOCATALITICOS PARA LA PREPARAC... 5K€ Cerrado

CCBioCat Biocatalytic C-C bond formation by repurposing transaminases 188K€ Cerrado

COMPBIOCATDESIGN Computational Design of Highly Active Biocatalysts of Intere... 256K€ Cerrado

Duración del proyecto: 69 meses Fecha Inicio: 2017-09-01
Fecha Fin: 2023-06-30

Líder del proyecto

FORSCHUNGSZENTRUM JULICH GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto There is an urgent need for the development of greener syntheses procedures if mankind wants to maintain an environment worth living in but is at the same time unwilling to accept a reduction in material comfort. The establishment of more biocatalytic steps in chemical syntheses is one possible solution, as enzymes and whole cells offer sustainable advantages, such as biodegradability, intoxicity, high selectivity, and many more. As a myriad of enzymatic reactions exist for almost any product, their potential is immense. Great scientific achievements and new techniques recently developed have enabled the design of economically and ecologically feasible multi-step enzyme cascades. However, with these new opportunities, also new challenges arise. The more enzyme steps are combined in one pot, the higher the risk of undesired cross-reactivity is. There is thus an urgent need for a tight control of each biocatalytic step in a cascade in order to obtain the desired product in a high purity and to make use of all advantages that enzyme cascades intrinsically offer. With LightCas, I aim to break new grounds in the area of multi-step (bio)catalysis by enabling an orthogonal, selective and thus flexible on/off tuning of enzymes in a cascade. By entrapping enzymes into light-switchable microgels, using photo-switchable active site lids and light-induced enzyme deactivation, three methods providing the opportunity to control enzyme activity in vitro and in vivo on demand will be (further) developed. The ultimate goal is to set up a one-pot multi-step light-controlled enzyme reactor yielding the desired product in high selectivity and concentration in a technically self-regulated manner. Beyond the ground-breaking direct impact in the field of enzyme catalysis, huge gains in knowledge are expected from LightCas with respect to the application of intelligent stimuli-responsive materials as well as new, advanced methods for applications in the clinical and research environment.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores