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GIAPHAGE

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Life of Giant Phages

Bacterial viruses, phages, are ubiquitous and most numerous entities in the biosphere. Development of sequencing techniques has increased our understanding on the diversity of phages that have not been isolated due to lack of cult... ver más

31/10/2028

UNIVERSITY OFJYVAS...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

JYVASKYLAN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-10

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

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1 Participantes

UNIVERSITY OFJYVASKYLAN

1.50M€ | Lider

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Duración del proyecto: 60 meses Fecha Inicio: 2023-10-10
Fecha Fin: 2028-10-31

Líder del proyecto

JYVASKYLAN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Bacterial viruses, phages, are ubiquitous and most numerous entities in the biosphere. Development of sequencing techniques has increased our understanding on the diversity of phages that have not been isolated due to lack of cultivable hosts and/or suitable isolation methods. While sequence data enables a better view to the viral diversity, at the same time lack of functional data and biological connection increases. Recently, different studies have found megaphages (mainly phages with a genome over 600 kbp) by assembling metagenomes from various environmental samples. However, no such isolates have been obtained thus far meaning that their characteristics and host interactions are completely unknown. In this ERC project, I will enlighten the life of giant phages, the term I coined for both jumbo and megaphages. I will achieve this by using the first megaphage isolates that I have isolated from boreal freshwaters. During the project, evidence on the megaphage structure, the host interactions and symbiotic relationship with host will be provided. Using a unique set of different phage sizes infecting the same host I will determine the size correlation to different life history traits. I will provide insight to the mutualistic relationship between bacteria and their viruses and reveal new mechanisms behind phage competition. I will also determine the environmental preferences for the megaphage emergence and abundance in boreal freshwaters. In this proposal, I aim to understand How, Where and When megaphages are isolated. Consequently, results will aid in understanding the role of megaphages in other environments such as gut microbiome and potentially provide avenues for developing new genetic tools. This project will open new understanding for microbial ecology and especially phage ecology and the project will create a new field of study under phage biology.

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