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Life-Inspired

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Life inspired complex molecular systems controlled by enzymatic reaction network...

Life inspired complex molecular systems controlled by enzymatic reaction networks Many of the key functions typically associated with living systems, including sensing of the environment, autonomous decision making, and extracting energy and building blocks from the environment for cell growth and division, are... ver más

31/03/2025

STICHTING RADBOUD...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-05-08

ERC-2018-ADG: ERC Advanced Grant Scope:Objectives

I+D

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2 Participantes

STICHTING RADBOUD UNIVERSITE...

2.50M€ | Lider

ALTIA CONSULTORES

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Duración del proyecto: 70 meses Fecha Inicio: 2019-05-08
Fecha Fin: 2025-03-31

Líder del proyecto

STICHTING RADBOUD UNIVERSITEIT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Many of the key functions typically associated with living systems, including sensing of the environment, autonomous decision making, and extracting energy and building blocks from the environment for cell growth and division, are all governed by enzymatic reaction networks. Constructing synthetic systems that capture some of these capabilities, i.e. life-inspired systems, would represent a truly disruptive development, as they challenge our notion of what differentiates living systems from synthetic, man-made devices. However, the ability create synthetic life-inspired systems remains an elusive goal. Despite impressive progress in systems chemistry, no clear engineering principles or methodologies exist for the bottom-up construction of functional complex molecular systems The translation of the design principles of living systems into programmable and functional life-inspired systems is one of the outstanding grand challenge in chemistry. The ultimate aim of this proposal is to construct life-inspired systems based on the design blueprints of living matter To achieve this aim, I propose a key breakthrough by presenting a completely new approach to functional complex systems based on programmable enzymatic reactions networks. The envisaged approach is modular and will allow for systematic increases in complexity. The core objectives of this proposal are: - establish a completely new approach to programmable enzymatic reaction networks - compartmentalize network motifs, and separate the small molecule ‘software’ from the enzyme ‘hardware’ - demonstrate modularity and increase the complexity via communication between compartments - develop robust methods to manage the maintenance of non-equilibrium conditions - design and construct complex life-inspired systems.

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