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EVOLVE

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Isolation and Analysis of Extracellular Vesicles using OptofLuidics for the eVal...

Isolation and Analysis of Extracellular Vesicles using OptofLuidics for the eValuation of Microsatellite Instability in Endometrial Cancer Endometrial cancer (EC) is the most common gynaecological cancer, and has an estimated incidence rise of more than 50% worldwide by 2040, mainly associated with increasing obesity prevalence. In 2018 alone, there were approximatel... ver más

31/08/2024

LABORATORIO IBERIC...

157K€

Presupuesto del proyecto: 157K€

Líder del proyecto

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-08-31

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

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Cerrada hace 3 años

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2 Participantes

LABORATORIO IBERICO INTERNAC...

156.78K€ | Lider

FUNDACION INSTITUTO DE INVES...

N.D. | Participante

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Duración del proyecto: 25 meses Fecha Inicio: 2022-07-19
Fecha Fin: 2024-08-31

Líder del proyecto

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 157K€

Descripción del proyecto Endometrial cancer (EC) is the most common gynaecological cancer, and has an estimated incidence rise of more than 50% worldwide by 2040, mainly associated with increasing obesity prevalence. In 2018 alone, there were approximately 380,000 new cases and close to 90,000 deaths attributed to EC worldwide. Thus, there is a growing need for the development of better platforms for inexpensive, early stage EC diagnosis and treatments. Immunotherapy has shown a sharp increase in survival rate in various cancers, but only in a small percentage of treated patients. The lack of reliable biomarkers for the selection of this sub-group of patients is a great hindrance to its broader application in the clinical setting. However, microsatellite instability (MSI) has been shown to be a good candidate for immunotherapy selection. MSI evaluation requires genetic material from tumors, which can be found in extracellular vesicles released by EC cells to the bloodstream. Isolation and Analysis of Extracellular Vesicles using OptofLuidics for the eValuation of Microsatellite Instability in Endometrial Cancer (EVOLVE) is thus a project focused on the development of an integrated solution for the enrichment and analysis of extracellular vesicles from body fluids of endometrial cancer patients to assess microsatellite instability using lab-on-chip, microfluidics methods in conjunction with DNA biomarkers and surface-enhanced Raman scattering technology.

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