embryonic rosettes
Financiado
Investigating embryonic development at the time of implantation using embryos an...
The mouse embryo is an excellent model for human development. Its preimplantation stages of development in vitro have been extensively studied. Now similar approaches can be applied to implantation stages, previously hidden from v...
The mouse embryo is an excellent model for human development. Its preimplantation stages of development in vitro have been extensively studied. Now similar approaches can be applied to implantation stages, previously hidden from view in the uterus. It was recently revealed that formation of a rosette structure by pluripotent epiblast cells can be recapitulated by ES cells cultured in extracellular matrix proteins. I will determine the extent to which such rosettes can undertake autonomous development or if they require flanking extraembryonic tissues. I will characterise the patterns of the normal development of these tissues from the point of implantation to the time of gastrulation. I will determine the extent to which explants of extraembryonic tissues can influence the development of rosettes of epiblast cells. Altogether, these experiments will expand our knowledge of embryonic development and how to manipulate the developmental potential of pluripotent cells.
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Duración del proyecto: 34 meses
Fecha Inicio: 2015-03-09
Fecha Fin: 2018-01-31
Fecha Fin: 2018-01-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2018-01-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2014-EF:
Marie Skłodowska-Curie Individual Fellowships (IF-EF)
Cerrada
hace 10 años
Presupuesto
El presupuesto total del proyecto asciende a
183K€
Líder del proyecto
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UN...
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Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
232.40K€ |
Participante