Intracellular Carrier Against Resistant microOrganisms (ICARO)
Intracellular pathogens and viruses elicit immune responses by presenting their antigens to T cells. At the same time, they have evolved immune evasion mechanisms which essentially reduce the antigenic repertoire that is presented...
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ARRAYS-FOR-CELL NANODEVICES
- la investigación, desarrollo, escalado, producción y/o comercialización de matrices de micropartículas planas de silicio cuya superficie s...
TRL
6-7
| 257K€
PARTICIPATION DEPralty
Sin fecha límite de participación.
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Project Information ICARO
Project duration: 48 months
Date Start: 2022-03-24
End date: 2026-03-31
Project leader
ARRAYS-FOR-CELL NANODEVICES
- la investigación, desarrollo, escalado, producción y/o comercialización de matrices de micropartículas planas de silicio cuya superficie s...
TRL
6-7
| 257K€
Project Budget
3M€
participation deadline
Sin fecha límite de participación.
Project description
Intracellular pathogens and viruses elicit immune responses by presenting their antigens to T cells. At the same time, they have evolved immune evasion mechanisms which essentially reduce the antigenic repertoire that is presented to the immune system. To overcome this problem, the EIC-funded ICARO project proposes to use silicon-based microchips that carry pathogen antigens and can be internalised by immune cells to aid antigen presentation. These biochips are retained within cells for a long time and will provide the foundation for a novel vaccination strategy that can boost specific and long-lasting T cell responses. The consortium aims to develop standardized methods for ICARO manufacturing and functionalisation to be easily applicable to different pathogens, thus accelerating the generation of new vaccines in the future