Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

INFLACOMM

Financiado

Cerrado

Interplay of inflammasomes commensals and pathogens at mucosal interfaces

Inflammasomes are multi-protein complexes that control the activity of the cysteine protease caspase-1. Inflammasomes are assembled around one of several different sensor proteins, which enable inflammasome activation after sensin... ver más

30/09/2017

HZI

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

HELMHOLTZZENTRUM FUR INFEKTIONSFORSCHUNG GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2017-09-30 No tenemos la información de la convocatoria

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

HZI

0.00€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

6-SENSE The role of NLRP6 sensing in regulation of intestinal host m... 100K€ Cerrado

META-BIOME Deciphering the molecular language orchestrating host microb... 2M€ Cerrado

INFLA-AID The role of NLRC4 inflammasome in autoinflammatory diseases 173K€ Cerrado

Tbet ILC JFN The role of innate lymphoid cells in regulating intestinal i... 183K€ Cerrado

IL-22 AND IL-22BP Identifying the immune and microbial network controlling the... 1M€ Cerrado

EPINFLAM Epithelial cells in inflammation 3M€ Cerrado

Líder del proyecto

HELMHOLTZZENTRUM FUR INFEKTIONSFORSCHUNG GMBH No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Inflammasomes are multi-protein complexes that control the activity of the cysteine protease caspase-1. Inflammasomes are assembled around one of several different sensor proteins, which enable inflammasome activation after sensing of diverse microbial and endogenous damage-associated molecules. Recently, I discovered a novel role for the NLRP6 inflammasome in regulation of the intestinal microbiota of mice. In its absence an altered microbiota, called dysbiosis, develops that increases the severity of experimentally-induced colitis. Strikingly, transfer of the altered microbiota to WT mice resulted in exacerbated colitis in these mice compared to normal WT mice. These findings highlight two important features of the interplay of host and microbiota. First, that deficiencies in the immune system may lead to pathologic aberrations in the commensal microbiota. In this proposal I will address how the NLRP6 inflammasome regulates the microbiota using newly generated gene-deficient mouse strains as well as germfree mouse models. The second implication is that the microbiota has a large effect on mucosal inflammatory processes that are largely regulated by its specific composition. Dysbiosis is observed in many human individuals with immune-mediated diseases, but its impact on other aspects of immunity is less well characterized. Hence, I intend to study the effects of the microbiota, specifically dysbiosis, on orchestrating anti-microbial immune responses, as well as the impact in host response to vaccination. Specifically, I will study vaccination and challenge models of bacterial and viral pathogens that enter through mucosal routes, i.e. Salmonella enterica and influenza virus. The knowledge emerging from this work is expected to expand our understanding of innate and adaptive immune responses to infection and pave the road for the development of new therapies and immune interventions against microbial pathogens.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores