Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

InterMet

Financiado

Intercellular trading in nucleotide metabolism: an emerging target

Anticancer therapy is >70 years old, and nucleotides are the oldest target in cancer treatment. Despite its long history, this treatment suffers high rates of resistance and toxicity. What are the reasons? A cell can gain nucleoti... ver más

28/02/2027

IBT INSTITUTE OF B...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

BIOTECHNOLOGICKY USTAV AV CR VVI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-03-14

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IBT INSTITUTE OF BIOTECHNOLO...

1.45M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SAF2014-56059-R ANALISIS DE LA REPROGRAMACION METABOLICA METASTASICA EN LA B... 266K€ Cerrado

PID2021-124765OB-I00 PROTEINAS TRANSPORTADORAS DE NUCLEOSIDOS (NTS) EN LA INTERSE... 236K€ Cerrado

BIO2014-56092-R BUSQUEDA DE NUEVAS HERRAMIENTAS DE INTERVENCION TERAPEUTICA... 145K€ Cerrado

SAF2012-38914 METABOLISMO BIOENERGETICO Y AUTOFAGIA EN LAS CELULAS MADRE T... 146K€ Cerrado

PID2021-124251OB-I00 CONTROL METABOLICO Y TRANSCRIPCIONAL DURANTE LA RESISTENCIA... 290K€ Cerrado

PRE2018-083938 NEUTRALIZACION DE LA REPROGRAMACION METABOLICA ASOCIADA A LA... 93K€ Cerrado

Duración del proyecto: 59 meses Fecha Inicio: 2022-03-14
Fecha Fin: 2027-02-28

Líder del proyecto

BIOTECHNOLOGICKY USTAV AV CR VVI No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Anticancer therapy is >70 years old, and nucleotides are the oldest target in cancer treatment. Despite its long history, this treatment suffers high rates of resistance and toxicity. What are the reasons? A cell can gain nucleotides via de novo synthesis (DNS) or from salvage pathways. DNS inhibition can be bypassed by nucleotides produced by surrounding cells or distant organs, causing resistance. Cancer cells were traditionally studied in isolation, with (bulk) techniques precluding identification of cell type-specific targets, causing toxicity. To date, the cellular sources of nucleotides in healthy and tumor tissues are poorly characterized. Can the complexity of metabolic crosstalk in tissues be captured by the traditional means? I hypothesize that cancer and stromal cells differ in how they utilize nucleic acid building blocks from external and internal sources. A single cell resolution is needed to disentangle their interactions, and inhibition of both DNS and cancer-specific salvage is required for a successful blockade. I aim to define the nucleotide sources in heathy tissues and tumors, characterize their adaptations to DNS blockade to uncover the network of metabolic interactions in tissues and find effective and specific combinations of targets. To reach this goal, I will use a unique combination of single cell multi-omics and tailored mouse models, an expertise and tools that I took the lead to set up. I will selectively disable DNS in the stroma (host mouse) and in cancer cells (syngeneic lung tumors) to generate tumors dependent on internally or externally produced nucleotides. In an integrative approach using spatial and single cell transcriptomics & metabolomics in situ, and functional genetic screen, I will search for targetable metabolic vulnerabilities of DNS-disabled cancer cells. This innovative research opens the path to understanding the organization of tissue metabolic homeostasis for new personalized metabolism-based anticancer medicine.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores