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Intelligent and reinforced tissue scaffolds for regenerative biomedicine

Calcium phosphate ceramics have been used in medicine for more than 20 years because of its similarities to bone apatite. Bone repair and regeneration occurs along its surface and porous structures permits bone ingrowths acting as... ver más

30/04/2011

UCM

45K€

Presupuesto del proyecto: 45K€

Líder del proyecto

Universidad Complutense de Madrid No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 3281

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2011-04-30 No tenemos la información de la convocatoria

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1 Participantes

UCM

0.00€ | Lider

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Líder del proyecto

Universidad Complutense de Madrid No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 3281

Presupuesto del proyecto 45K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Calcium phosphate ceramics have been used in medicine for more than 20 years because of its similarities to bone apatite. Bone repair and regeneration occurs along its surface and porous structures permits bone ingrowths acting as a scaffold in bony tissues sites. As well as these ceramics, bioactive glasses and biocompatible polymers are widely used but all of them present low strength and poor fatigue resistance to be implanted as high load bearing devices. In order to seek better ways of processing biomaterials, so that both mechanical properties and porosity could be optimized, devices have been design combining HA with other materials, however, significant amounts of the reinforcing phases are needed to achieve the desired properties, and as these parts are significantly less bioactive than HA, or bioreabsorble, the ability of the composite to form a stable interface is poor compared to HA itself. An ideal reinforcement material would impart mechanical integrity without diminishing its properties. This project envisages the use of carbon nanotubes (CNTs) as reinforcement material for the bioactive ceramics and to use their ability as drug delivery systems of pharmacological active molecules (osteogenic, antitumoral, antiviric,…) or as smart materials (able to change their properties as a function of the medium). In relation to this, the addition of CNTs to the base composite produces a three-dimensional electrical conducting network, property as has already been reported, could be used to provide electrical stimulation and increase of cellular proliferation.

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