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SpaceClones

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Integrative profiling and engineering of clonal cancer cell behaviours from the...

Integrative profiling and engineering of clonal cancer cell behaviours from the tissue level down to the molecular scale Clonal evolution in tumours, the process by which cancer cells expand, diversify and are selected, is a major determinant of tumour growth and response to therapy. How the co-existence of diverse cancer cell clones shape tumour de... ver más

31/12/2028

FUNDACIO INSTITUT...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUN... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-11-15

ERC-2023-STG: ERC STARTING GRANTS Scope:Objectives

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Cerrada hace 2 años

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1 Participantes

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2.50M€ | Lider

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Duración del proyecto: 61 meses Fecha Inicio: 2023-11-15
Fecha Fin: 2028-12-31

Líder del proyecto

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUN... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Clonal evolution in tumours, the process by which cancer cells expand, diversify and are selected, is a major determinant of tumour growth and response to therapy. How the co-existence of diverse cancer cell clones shape tumour development is a fundamental question that remains open, in part because of limitations on existing experimental platforms and analytical frameworks. Our expertise inferring multicellular behaviours within tissue microenvironments, together with recent advances in imaging, assay automation, and cell engineering, timely place us in an excellent position to profile and engineer clonal interactions within tumours from the tissue level down to the molecular scale, which enables targeting this important question with unprecedented throughput and spatial resolution. In SpaceClones, we aim to: (1) characterize clonal interactions in genetically engineered tumours at sub-100 nm resolution, (2) characterize clonal signatures under metabolically defined environmental conditions, and (3) examine the cell state of engineered clonal spatial patterns. To overcome a variety of challenges to understanding molecular and cellular mechanisms of clonal behaviours in tumours, I have designed a ground-breaking approach that combines highly-multiplexed imaging, in vitro and in vivo tumour models, cell engineering, super-resolution microscopy, combinatorial low-volume liquid handling, and algorithms for deconstruction of spatial patterns. Altogether, SpaceClones will exemplify how to imply causality on the emergence of clonal spatial patterns in tumours, having far-reaching implications for the study of any other multicellular system. Ultimately, a deeper understanding of clonal evolution will contribute in the design of more effective cancer therapies and tools to predict clinical outcomes.

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