Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

bAIes

Financiado

Integrative, AI-aided Inference of Protein Structure and Dynamics

The life sciences community is living in exciting times. During the past year, Artificial Intelligence (AI), and in particular AlphaFold2, has contributed to advancing our understanding of protein behaviour by enabling structure p... ver más

31/07/2028

CNRS

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-17

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

2.93M€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

EMMA Exploring the molecular grammar of IDP assembly and condensa... 2M€ Cerrado

MARMOTTE Tessellation-based analysis of dynamic protein structures an... 196K€ Cerrado

RYC2021-034367-I Deep Unsupervised Language Models for Protein Engineering 236K€ Cerrado

BFU2011-24595 HACIA LA PREDICCION DE LOS CAMBIOS DE ESTRUCTURA DE PROTEINA... 42K€ Cerrado

PID2020-116564GB-I00 POTENCIALES DE REDES NEURONALES PARA LA PROXIMA GENERACION D... 248K€ Cerrado

TIN2011-27294 OPTIMIZACION EVOLUTIVA DE PROCESOS EMERGENTES MODELADOS CON... 8K€ Cerrado

Duración del proyecto: 64 meses Fecha Inicio: 2023-03-17
Fecha Fin: 2028-07-31

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Descripción del proyecto The life sciences community is living in exciting times. During the past year, Artificial Intelligence (AI), and in particular AlphaFold2, has contributed to advancing our understanding of protein behaviour by enabling structure prediction with accuracy comparable to many experimental techniques at a fraction of their time and costs. However, structures are only a piece of the puzzle. To understand the mechanisms underlying biological functions, we need to characterize the conformational landscape of proteins, the population of relevant states, and their pathways of interconversion. Furthermore, we need to determine the effect of the environment in modulating structures, populations, and pathways, as biological systems perform their functions in the complexity of cells rather than in the isolation of test tubes. None of these objectives can be achieved by AI structure-prediction methods alone. In this proposal we will leverage the PI’s expertise in the field of integrative computational-experimental techniques to develop, apply, and disseminate bAIes, a modelling approach that will enable attaining these goals. bAIes will make synergistic use of AI structural models, experimental data, and molecular simulations driven by accurate physico-chemical models to characterize protein structure and dynamics. We will demonstrate how bAIes can solve biological problems that exceed the capabilities of AI approaches, such as the characterization of protein disordered regions and the determination of structure and dynamics in situ, with a particular focus on the SARS-CoV-2 spike protein. The outcome of this proposal will be a versatile, accurate and efficient method that will push the boundaries of what can be achieved with AI structure-prediction methods. bAIes will be implemented in the widely used PLUMED library, of which the PI is founder and core developer, thus enabling its application to a wide variety of systems and biological problems beyond those envisioned here.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores