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ETOX

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Integrating bioinformatics and chemoinformatics approaches for the development o...

Integrating bioinformatics and chemoinformatics approaches for the development of expert systems allowing the in silico prediction of toxicities The eTOX consortium proposes to develop innovative methodological strategies and novel software tools to better predict the toxicological profiles of new molecular entities in early stages of the drug development pipeline. This wi... ver más

31/12/2016

NOVARTIS

19M€

Presupuesto del proyecto: 19M€

Líder del proyecto

NOVARTIS PHARMA AG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 27 Participantes

Financiación concedida El organismo FP6 notifico la concesión del proyecto el día 2016-12-31 No tenemos la información de la convocatoria

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27 Participantes

NOVARTIS

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FUNDACION SECTOR PUBLICO EST...

N.D. | Participante

CHEMOTARGETS

N.D. | Participante

Fundació Institut Hospital d...

N.D. | Participante

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Duración del proyecto: 83 meses Fecha Inicio: 2010-01-01
Fecha Fin: 2016-12-31

Líder del proyecto

NOVARTIS PHARMA AG No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 19M€

Descripción del proyecto The eTOX consortium proposes to develop innovative methodological strategies and novel software tools to better predict the toxicological profiles of new molecular entities in early stages of the drug development pipeline. This will be achieved by coordinating the efforts of specialists from academia and SMEs in the wide scope of disciplines that are required to move towards a more reliable modelling of the complex relationships existingbetween molecular and in vitro information and the in vivo toxicity outcomes of drugs. The proposed strategy includes a synergetic integration of innovative approaches in the following areas:Database building and management, including masking procedures for sensitive data, with the aim of facilitating the sharing of information among pharmaceutical companies.• Ontologies and text mining techniques, with the purpose of facilitating knowledge extraction from legacy preclinical reports and biomedical literature.• Chemistry and structure-based approaches for the molecular description of the compounds considered, as well as of the biological anti-targets responsible for the secondary pharmacologies.• Prediction of absorption and metabolism since these ADME properties are often critically related to toxicological events.• Computational genomics to afford the inter-species and inter-individual variabilities that complicate the interpretation of experimental and clinical outcomes.• Systems biology approaches in order to cope with the complex biological mechanisms which govern in vivo safety problems.• Sophisticated statistical analysis tools required to derive the inevitably highly-multivariate QSAR models.• Development and validation (according to the OECD principles) of QSARs, integrative models, expert systems and meta-tools.• Linkage of toxicity preclinical data with human outcomes

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