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CNS2023-144492

Financiado

Microelectrónica, nanotecnología y fotónica

ADVANCES ON NEUROTECHNOLOGIES CAPABLE FOR HIGH-DENSITY MAPPING OF WIDE-BANDWIDTH ELECTROPHYSIOLOGICAL BRAIN ACTIVITY ARE OF PARAMOUNT IMPORTANCE FOR A BETTER UNDERSTANDING OF BOTH THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL BRAIN. NO... ver más

01/01/2023

CSIC

400K€

Presupuesto del proyecto: 400K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Ver 1 Participantes

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2023-01-01

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1 Participantes

CSIC

399.96K€ | Lider

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Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA...

TRL 2-3 | 552M€

Presupuesto del proyecto 400K€

Descripción del proyecto ADVANCES ON NEUROTECHNOLOGIES CAPABLE FOR HIGH-DENSITY MAPPING OF WIDE-BANDWIDTH ELECTROPHYSIOLOGICAL BRAIN ACTIVITY ARE OF PARAMOUNT IMPORTANCE FOR A BETTER UNDERSTANDING OF BOTH THE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL BRAIN. NOWADAYS, MAINSTREAM BRAIN MAPPING DEVICES RELY ON PASSIVE METAL ELECTRODES. THESE ELECTRODES REQUIRE ITS OWN WIRE TO ROUTE SIGNALS OUTSIDE THE BRAIN, LIMING THE ADOPTION OF MULTIPLEXED READOUT TO INCREASE DENSITY AND RESOLUTION. ALTERNATIVELY, ACTIVE TRANSDUCERS BASED ON GRAPHENE MICROTRANSISTORS WHICH HAVE BEEN PREVIOUSLY DEVELOPED BY THE IP OF THIS PROPOSAL HAVE BEEN DEMONSTRATED THAT ARE CAPABLE TO MONITOR THE BRAIN ACTIVITY WITH VERY HIGH SPATIAL RESOLUTION AND OVER A WIDE BANDWIDTH FREQUENCY RANGE (INCLUDING INFRALOW FREQUENCIES, WHICH ARE NOT POSSIBLE TO RECORD WITH STANDARD MICROELECTRODES), AND DEMONSTRATING MULTIPLEXING CAPABILITIES UP TO 1024 CHANNELS. HOWEVER, THESE DEVELOPED NEUROPROBES BASED ON SWITCHLESS ARRAYS PRESENT A NON-DEPRECIABLE CROSS-TALK BETWEEN RECORDING CHANNELS.THE USE OF 2D LAYERED MATERIALS CAN REPRESENT A NEW PARADIGM IN MICROELECTRONICS. THEIR PROPERTIES TOGETHER WITH THE POSSIBILITY TO STACK THEM IN DIFFERENT HETEROSTRUCTURES PAVES THE WAY TO CONSTRUCT NEW MICROELECTRONIC STRUCTURES THAT COULD BE INTEGRATED IN MANY SUBSTRATES. IN THIS SENSE, THEIR USE IN THE FIELD OF NEUROELECTRONIC OPENS THE DOOR TO OVERCOME THE LIMITATIONS OF THE CURRENT FLEXIBLE NEUROPROBES TO A NEW GENERATION OF FLEXIBLE DEVICES CAPABLE TO PERFORM HIGH-DENSITY RECORDINGS OF BRAIN SIGNALS BY INTEGRATING ONSITE SWITCHES BASED ON 2D MATERIALS.IN PARTICULAR, THE 2D-NEURO PROJECT PROPOSES I) THE DEVELOPMENT OF NOVEL FABRICATION STRATEGIES FOR THE FLEXIBLE GRAPHENE MICROTRANSITIR ARRAYS TO INCREASE THEIR RECORDING CAPABILITIES AND COMPATIBILITIES; AND II) THE DEVELOPMENT AND INTEGRATION OF OTHER 2D LAYERED MATERIALS FOR THE IMPLEMENTATION OF ONSITE ELECTRONIC SWITCHES TO IMPROVE THE SIGNAL READ-OUT IN HIGH CHANNEL COUNT MULTIPLEXED GRAPHENE MICROTRANSISOR ARRAYS. FOR THAT, THIS PROPOSAL PRETENDS TO SET-UP DE GROWTH AND TRANSFER OF H-BN, TOGETHER WITH ITS INTEGRATION AND THE MOS2 INTEGRATION TO THE THIN FILM TECHNOLOGY WHICH HAS ALREADY INTEGRATED THE GRAPHENE MICROTRANSISTORS, AND HAS ALREADY DEMONSTRATED UNPRECEDENTED PROPERTIES FOR BRAIN SIGNAL RECORDING. FINALLY, THE ADOPTION OF 2D LAYERED MATERIALS IN THE MICRO AND NANOFABRICATION CLEAN ROOM OF THE IMB-CNM WILL NOT ONLY FULFILL THE OBJECTIVES OF THIS PROPOSAL, BUT IT WILL SERVE TO ESTABLISH A NEW RESEARCH ACTIVITY IN THE IMB-CNM FOCUSED ON USING 2D MATERIALS TO OVERCOME THE LIMITS THAT WILL EVENTUALLY FACE THE CMOS-BASED MICROELECTRONICS. MATERIALES BIDEMINSIONALES\NEUROFISIOLOGIA\MICROFABRICACION\GRAFENO

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