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PLASTICHEAL

Financiado

Cerrado

Innovative tools to study the impact and mode of action of micro and nanoplastic...

Innovative tools to study the impact and mode of action of micro and nanoplastics on human health towards a knowledge base for risk assessment The exponential increase in the production/use of plastic translates into a parallel increase of environmental plastic-waste that is continuously degraded into micro and nanoplastics (MNPLs). Information on the MNPLs effects on hu... ver más

31/03/2025

UAB

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

UNIVERSITAT AUTÒNOMA DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 1265

Fecha límite participación Sin fecha límite de participación.

Ver 15 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-01-29

SC1-BHC-36-2020: Micro- and nano-plastics in our env...

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Cerrada hace 4 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

15 Participantes

UAB

1.43M€ | Lider

FUNDACIO PARC DE RECERCA

164.38K€ | Participante

84.75K€ | Participante

FUNDACIO INSTITUT D'INVESTIG...

50.00K€ | Participante

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Duración del proyecto: 50 meses Fecha Inicio: 2021-01-29
Fecha Fin: 2025-03-31

Líder del proyecto

UNIVERSITAT AUTÒNOMA DE BARCELONA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 1265

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The exponential increase in the production/use of plastic translates into a parallel increase of environmental plastic-waste that is continuously degraded into micro and nanoplastics (MNPLs). Information on the MNPLs effects on human health is still preliminary and, furthermore, the limitations in current methodologies prevent accurate human exposure/risk assessment. In this context, PLASTICHEAL aims at providing new methodologies and solid scientific evidence to regulators by combining the use of breakthrough research and validated test methods to set the knowledge basis for adequate risk assessment of MNPLs. PLASTICHEAL will be supported by an innovative experimental approach that will first generate human exposure estimates after identification, measurement, and characterization of MNPLs present in the environmental air, water and food sources, as well as in human biological samples of population groups with potential high MNPLs exposure levels (biomonitoring study) by means of adapting the existing analytical methodology proven useful for fibres and nanomaterials. Those estimates will then be complemented/ correlated with the output of kinetic models using data on MNPLs translocation, accumulation and destabilization of the Gastrointestinal and Respiratory Tracts, and with the MNPLs toxicokinetic in blood and secondary organs using in vivo models. Thereafter, immune effects, transforming effects, genotoxic effects, impact on transcriptome/epigenome/secretome (i.e. omics), stemness imbalance and potential molecular mechanisms of action and adverse outcome pathways in blood, primary and secondary organs will be studied under in vitro, in vivo, and ex vivo short and long-term (co)exposure settings. To ensure the impact of PLASTICHEAL’s developed methodology and gained knowledge on current and future regulation, a continuous dialogue will be established from the beginning of the project with policy makers and other key stakeholders of the plastic value chain. PLASTICHEAL is part of the European MNP cluster on human health (Name and acronym to be decided).

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