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MODELMOOD

Financiado

Cerrado

INNOVATIVE APPROACHES TO PHENOTYPE MOOD DISORDERS IN MOUSE MODELS

"Major depression is a potentially life-threatening illness affecting 10-15% of the population and causing an enormous economic burden (Euros 120 billions/year in Europe), also due to incomplete efficacy of antidepressants. The mo... ver más

31/01/2014

UZH

128K€

Presupuesto del proyecto: 128K€

Líder del proyecto

University of Zurich No se ha especificado una descripción o un objeto social para esta compañía.

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2014-01-31 No tenemos la información de la convocatoria

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UZH

128.18K€ | Lider

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Líder del proyecto

University of Zurich No se ha especificado una descripción o un objeto social para esta compañía.

Presupuesto del proyecto 128K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Major depression is a potentially life-threatening illness affecting 10-15% of the population and causing an enormous economic burden (Euros 120 billions/year in Europe), also due to incomplete efficacy of antidepressants. The most relevant cause of this is the poor knowledge of the neural basis for mood regulation that has to be attributed, among other factors, to the limited information gathered from animal models. The main aim of the present project is setting up an innovative strategy for comprehensive, detailed phenotyping of mouse models of depression. Experimental protocols for investigating behavioural responses involved in the depression phenotype, such as pessimistic bias and an altered social behaviour, will be developed in an automated apparatus. These protocols will be used in combination with already validated protocols (e.g. anhedonia, sleep/wake cycle) to obtain a comprehensive, automated and high-throughput phenotyping strategy to assess depression-like behaviour in mice and to screen antidepressant action. Translation research resulting into clinical application for brain research is a central priority in Europe in the context of psychiatric disorders. The high throughput screening combined with strong hypothesis on the evolutionary basis of the behaviours to be modelled can have important consequences on the health, societal and economic burden imposed by major depression, leading to improved drug development. Being able to work in an environment where industry and academia collaborate strongly, such as the host environment, will allow the candidate to better exploit new knowledge for its technological transfer into SME products and will lead to a close cooperation with leading scientists and engineers. Ultimately the opportunity given by this fellowship will endow him with the necessary skills to develop his own research team and to advance the field on innovative animal models for the study of mood disorders."

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