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NEADMIX

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Inferring hominin population history through space and time using introgressed h...

Inferring hominin population history through space and time using introgressed haplotypes In the last decade, ancient DNA studies have increased their throughput from single samples to thousands of genomes published every year, giving us unprecedented data about human genetic history. However, tools and methods that ef... ver más

30/04/2027

MPG

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-01-25

ERC-2021-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

MPG

1.50M€ | Lider

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Duración del proyecto: 63 meses Fecha Inicio: 2022-01-25
Fecha Fin: 2027-04-30

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto In the last decade, ancient DNA studies have increased their throughput from single samples to thousands of genomes published every year, giving us unprecedented data about human genetic history. However, tools and methods that efficiently use this wealth of data are sorely lacking, especially because DNA extracted from fossils is often scarce and contaminated. In this project, I develop population genetic theory and bioinformatic methods that use ancient DNA to refine estimates of when and where archaic and modern humans interbred, to characterize the historical, biological and functional consequences of this gene flow, and to learn about the differences between modern humans, Neandertals, and Denisovans. The first aim of this project is to develop a robust and general genotype-likelihood approach for local ancestry inference that allows efficient use of contaminated, low-coverage data, and to establish approximate haplotype-based methods for inferring introgression tracts. The second aim of the project is to develop the necessary population genetic theory and statistical methods to translate the inferred haplotypes into biological insights. The proposed theoretical, numerical and simulation-based approaches will link the inferred introgression patterns with the underlying population genetic processes. The final aim is to apply these novel tools to study where and when gene flow between Neandertals, Denisovans, and modern humans occurred. I also aim to identify introgressed haplotypes that are a target of natural selection and to quantify the relative importance of positive, negative, and balancing selection on Neandertal and Denisovan gene flow. As a result, this work will expand the tool set available for the analysis of ancient DNA, reveal the precise history of the interactions of Neandertals and modern humans, and provide answers to the key question of what genetic factors contributed to the survival of our species, while all other hominins went extinct.

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