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iPhotoreceptors

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Inducible Human Photoreceptors for Research Development and Therapy to Prevent...

Inducible Human Photoreceptors for Research Development and Therapy to Prevent Blindness One of the major causes of adult visual impairment and blindness in industrialized countries is the progressive dysfunction and death of photoreceptor cells (PR) as a result of retinal degenerative diseases. Current treatment opti... see more

30/09/2022

UKB

150K€

Project Budget: 150K€

Project leader

UNIVERSITATSKLINIKUM BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2022-09-30

ERC-2020-POC: Call for proposals for ERC Proof of... Scope:Objectives:

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Cerrada does 5 years

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

UKB

130.64K€ | Leader

ROTATEK

1.25M€ | participant

TUTECH INNOVATION GMBH

19.36K€ | participant

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Project duration: 18 months Date Start: 2021-03-30
End date: 2022-09-30

Project leader

UNIVERSITATSKLINIKUM BONN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 150K€

participation deadline Sin fecha límite de participación.

Project description One of the major causes of adult visual impairment and blindness in industrialized countries is the progressive dysfunction and death of photoreceptor cells (PR) as a result of retinal degenerative diseases. Current treatment options are still insufficient to counteract these forms of blindness. The development of many drugs and therapies fail in preclinical stages because the used animal models are suboptimal for translating results from the bench to the bedside. Especially, for testing the transplantation of human PRs, which is currently extensively explored as a treatment option for late stages of retinal degeneration, the biggest bottleneck is the lack of PR material in sufficient quantity and quality. Within the ERC Starting Grant ProNeurons, my team and I have developed a disruptive technology to differentiate human induced pluripotent stem cells (hiPSCs) to PR precursor cells by overexpressing three transcription factors yielding in up to 60% in only 10 days. Our technology allows fast, efficient and unlimited production of PRs essential as testbeds for drug screenings, for further disease research and for photoreceptor replacement therapies. Within the PoC actions, we strive for bringing the induced PRs closer to the market. We will finalize the last product development steps and FTO reviews to define the final products such as PR differentiation kits and/or cryopreserved PRs for research, development and therapy. We will identify and approach industrial exploitation partners for out-licensing or further funding. The final goal of commercializing the induced PRs is to aid the development of new drugs to treat retinal degenerative diseases.

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