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SILICOFCM

Financiado

Cerrado

In Silico trials for drug tracing the effects of sarcomeric protein mutations le...

In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease o... ver más

28/02/2022

ISTRAZIVACKO RAZVO...

6M€

Presupuesto del proyecto: 6M€

Líder del proyecto

ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 17 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-02-28

SC1-PM-16-2017: In-silico trials for developing and... Specific Challenge:In biomedical, pharmaceutical and toxicology research, the safety and efficacy of...

I+D

Cerrada hace 8 años

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Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

17 Participantes

ISTRAZIVACKO RAZVOJNI CENTAR...

721.75K€ | Lider

MFUNS UNIVERSITY OF NOVI SAD...

49.85K€ | Participante

UNIKENT

413.55K€ | Participante

SEVEN BRIDGES GENOMICS UK LT...

103.27K€ | Participante

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Duración del proyecto: 45 meses Fecha Inicio: 2018-05-08
Fecha Fin: 2022-02-28

Líder del proyecto

ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 6M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC). Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally. SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM. The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retrospective and prospective studies. SME partner R-Tech will be in charge of regulatory issues and reports and BIOIRC will do the exploitation of the project.

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