Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

INJURMET

Financiado

Cerrado

Impact of tissue injury induced by diagnostic biopsies and surgery on cancer met...

Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis Background: Blood-borne metastasis of malignant cells from the primary lesion to distant organs is the major cause of cancer-related death. Most cancer patients face tissue injury at initial diagnosis when tumor tissue is obtained... ver más

31/07/2025

UKE

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITAETSKLINIKUM HAMBURGEPPENDORF No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-07-23

ERC-2018-ADG: ERC Advanced Grant

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UKE

2.50M€ | Lider

BURES

531.12K€ | Participante

Proyectos interesantes

PID2019-103899RB-I00

Medical Technol...

Data Science

206K€ Cerrado

META-BREAST-CA

Medical Technol...

Data Science

100K€ Cerrado

SAF2011-29699

Medical Technol...

Data Science

242K€ Cerrado

PRE2020-092859

Medical Technol...

Data Science

99K€ Cerrado

PRE2020-092859

Medical Technol...

Data Science

99K€ Cerrado

CanDo

Medical Technol...

Data Science

5M€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 72 meses Fecha Inicio: 2019-07-23
Fecha Fin: 2025-07-31

Líder del proyecto

UNIVERSITAETSKLINIKUM HAMBURGEPPENDORF No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Background: Blood-borne metastasis of malignant cells from the primary lesion to distant organs is the major cause of cancer-related death. Most cancer patients face tissue injury at initial diagnosis when tumor tissue is obtained by biopsies to secure the diagnosis of cancer and at primary surgery required to remove the primary tumor. Objectives: We will evaluate whether tissue injury contributes to a significant blood-borne dissemination of viable tumor cells, which is one of the most under-investigated areas in cancer research. We will focus on the two most frequent malignancies in women (breast cancer) and men (prostate cancer) that occur in the in European Union with incidence rates of 139.5 and 139.0 cases per 100,000, respectively. The current project will study the extent of the release of tumor cells into the blood circulation after needle tissue biopsies and primary surgery, the characteristics of the released tumor cells and the contribution of this release to cancer progression. Moreover, we will assess therapeutic strategies to block extravasation of circulating tumor cells (CTCs) to distant sites. As experimental approach, we will apply novel technologies for capturing CTCs and for determining their molecular characteristics in cancer patients as well as experimental models that are able to determine the functional properties of CTCs. Impact: The results will have an important impact on medical practice. If biopsies would contribute to tumor progression, it might be a strong driving force for the development of better imaging modalities or liquid biopsy assays of peripheral blood that can diagnose cancer through the detection of CTCs or tumor cell products such as circulating nucleic acids (DNA, microRNA), exosomes or tumor-educated platelets. Moreover, short-term pharmacologic inhibition of extravasation might be able to prevent the extravasation of injury-released CTCs and reduce the risk of metastasis.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores