Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ENERGISED

Financiado

Cerrado

Impact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And...

Impact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And In Inflammatory bowel disease Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized byinappropriate gut inflammation. Their incidence has increased dramatically in Western countries in r... ver más

31/08/2027

SORBONNE UNIVERSIT...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

SORBONNE UNIVERSITE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-09-01

ERC-2021-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

I+D

Cerrada hace 3 años

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

Participantes

SORBONNE UNIVERSITE

Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

MUCO-IMMUN MUCOBIOME MEDIATED IMMUNE PATHWAYS IN INFLAMMATORY BOWEL DIS... 166K€ Cerrado

MUTFLYGUTBACT Host intestinal bacteria mutualism Learning on the fly... 1M€ Cerrado

RYC-2010-07051 Role of the intestinal microbiota in inflammatory bowel dise... Cerrado

IJCI-2017-32485 Influencia de la microbiota intestinal en el metabolismo y l... 64K€ Cerrado

IMMUNOBIOME Identifying microbiotal triggers of inflammatory bowel disea... 2M€ Cerrado

MAGI Microbial therapy against gut inflammation 148K€ Cerrado

Duración del proyecto: 59 meses Fecha Inicio: 2022-09-01
Fecha Fin: 2027-08-31

Líder del proyecto

SORBONNE UNIVERSITE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized byinappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a rolefor environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion ofpatients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis andidentification of new therapeutic targets are therefore urgently needed. In this context, the gut microbiota has been recognized as astrong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in thepathogenesis. Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunitysensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mountingthe appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it. I hypothesize that thealtered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis. The aims ofENERGISED are to (i) identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and themechanisms involved and (ii) decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD anddesign new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD.This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use ofmultiple cutting-edge technologies; and translational analysis from mice to humans. In addition to its scientific importance, it willhave societal impacts due to the identification of new therapeutic strategies.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores